rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Beneficial Effects of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD)
  name:
    name part: Guo, Ting
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Wu, Chaodong
    role:
      role term: thesis advisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Nonalcoholic fatty liver disease (NAFLD) is currently a worldwide problem associated with diabetes, obesity, heart diseases, and insulin resistance. The pathogenesis of NAFLD is divided into simple steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and cirrhosis finally, lipid deposition and chronic inflammation are the main markers. There is still no effective medicine for the therapy of NAFLD, specifically in the NASH stage. Berberine (BBR) is a natural product isolated from plants such as Coptis chinensis Franch, and it has been reported it had beneficial pharmacological activities in a series of metabolic diseases, focusing on adenosine monophosphate-activated protein kinase (AMPK) pathway. BBR showed anti-hyperglycemic and anti-hyperlipidemic effects in diabetes and obesity patients and animal models. It improved insulin sensitivity in these reports and our experiment. We found BBR improved insulin resistance and glucose intolerance in HFD mice, without body weight or food intake difference. BBR ameliorates fat deposition in liver, through reducing lipogenesis related genes expression. Meanwhile, BBR decreased inflammation in liver and adipose tissue. BBR inhibited JNK pathway and activated AMPK phosphorylation in hepatocytes, but not in the macrophages. Thus, the function cells may be the main cell type that responds to BBR in liver, and maybe BBR down-regulates lipogenesis through inhibiting Akt. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/155174
  note: by Ting Guo.
  note: "Major Subject: Nutrition"
  note: Includes vita.
  note: Master of Science Texas A & M University 2015 http://hdl.handle.net/1969.1/155174
  note: Includes bibliographical references.
  note: Text (Thesis)
  subject:
    topic: Major Nutrition
  subject:
    topic: Nonalcoholic fatty liver disease
  subject:
    topic: berberine
  subject:
    topic: lipogenesis
  subject:
    topic: inflammation
  subject:
    topic: high-fat diet
  subject:
    topic: AMPK
  subject:
    topic: ACC
  subject:
    topic: JNK 1
  identifier: http://hdl.handle.net/1969.1/155174
  record info:
    record content source: TXA
    record creation date: 160308
    record change date: 20170928112501.0
    record identifier: in00003610382
    language of cataloging:
      language term: eng