Genes and Mechanisms in Vertebrate Sex Determination /
Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determinatio...
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| Format: | eBook |
| Language: | English |
| Published: |
Basel :
Birkhäuser Basel : Imprint : Birkhäuser,
2001.
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| Series: | Experientia. Supplementum ;
91. |
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| Online Access: | Connect to the full text of this electronic book |
| Summary: | Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions. |
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| Item Description: | Electronic resource. |
| Physical Description: | 1 online resource (xii, 205 pages) |
| ISBN: | 9783034877817 (electronic bk.) 3034877811 (electronic bk.) |
| ISSN: | 1023-294X ; |