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Restoring Function to the Injured Human Spinal Cord
1 online resource (xvi, 161 pages 32 illustrations, 30 illustrations in color.)
Of catastrophic traumas to the human body, spinal cord injury (SCI) has least benefited from innovations arising from the new biology. Since after WW II, the "standard of care" for SCI has changed little. The controversial use of high dosages of steroids has provided only modest benefit to patients - but not without the enhanced risk of mortality. Novel therapies arising form biochemistry and genetics have not materialized in over 15 years, and are unlikely to in the author's opinion. Instead, appreciation of biophysics and cell physiology in controlling nerve injury, growth, regeneration, and function has produced innovative clinical approaches now in testing in human spinal cord injury.
From the contents: A brief primer on spinal cord injury -- The behavioral catastrophe is rooted in injury to white matter -- The scar as a barrier to regeneration -- Treating the acute and chronic injury: historical perspective -- Concerning behavioral models for spinal cord injury in animals -- Axonal regeneration -- Treatment possibilities of the new biology -- Biologically produced electrical fields: physiological spoken here -- Endogenous voltages and the reaction of the neuron to injury -- The responses of isolated nerve fibers in culture to applied DC voltages: historical perspective -- Enhancing spinal cord regeneration in situ with applied electrical fields -- Recovery of the CTM reflex in spinal injured guinea pigs after exposure to applied extracellular voltages -- From a laboratory tool to a clinical application.
Includes bibliographical references (pages 141-155) and index.
Advances in anatomy, embryology, and cell biology ; 171