Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate /
Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechani...
| Main Author: | |
|---|---|
| Corporate Author: | |
| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg,
2002.
|
| Series: | Research and perspectives in Alzheimer's disease.
|
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Regulated intramembrane proteolysis
- new lessons from lipid metabolism and the unfolded protein response
- Notch signaling in the brain: more than just a developmental story
- Control of notch activity by the ubiquitin-proteasome pathway
- A presenilin-dependent S3-like gamma-secretase cleavage of the beta-amyloid precursor protein
- New non-peptide inhibitors of gamma-secretase abolish A-beta production without modyfying notch cleavage
- Presenilins, APP, and notch: proteolysis from womb to tomb
- Missorting of the dendritic cell adhesion molecule telencephalin in presenilin-deficient neurons
- Beta-APP processing, its biology and Alzheimer's disease
- Further analysis of the nicastrin: presenilin complex
- PS1 interacts with and facilitates beta-catenin turnover
- Delta-catenin, presenilin, and the synaptic-adherens junction complex
- Vascular smooth muscle cells are the primary target of the events leading from notch3 mutations to CADASIL.