rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Cell Kinetic Modelling and the Chemotherapy of Cancer
  name:
    name part: Knolle, Helmut.
    role:
      role term: creator
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: gw
    date issued: 1988
    issuance: monographic
  language:
    language term: eng
  physical description:
    reformatting quality: access
    form: remote
    extent: 1 online resource (viii, 157 pages)
  abstract: This monograph establishes a necessary link between experimental cancer research and mathematical modelling of cell population and presents a new approach to the old problem of building a rational basis for the design of radio- and chemotherapy of cancer. Rather than embark straightaway on model-building the author gives priority to the determination of action parameters of cytotoxic drugs. A survey of autoradiographic experiments and evaluation methods in cell kinetics is given, and classical formulae in this field are improved or generalized. The cell cycle retarding effect of certain drugs which in the past, raised some controversy, is described in a concise quantitative frame-work. Finally, a mathematical model of cell populations under treatment is tested against data from experiments with cell cycle phase-specific drugs and is applied to the problem of choosing optimal time schedules of chemotherapy. The book will serve as a guide to mathematical cell kinetics for biologists, as well as an introduction to the biomedical environment of the field for mathematicians. A knowledge of matrix algebra, calculus, and ordinary differential equations is expected of the reader, but is not essential for using the results in the design and evaluation of cell kinetic experiments.
  table of contents: Mathematical Models of Cell Populations -- Determination of Cell Kinetic Parameters -- Cell Kinetics and Cancer Therapy -- Appendix -- List of Symbols -- References -- Subject Index.
  note: by Helmut Knolle.
  note: Electronic resource.
  subject:
    topic: Mathematics
  subject:
    topic: Cytology
  subject:
    topic: Statistics
  subject:
    topic: Cytology
  subject:
    topic: Mathematics
  subject:
    topic: Statistics
  classification: QH323.5
  classification: QH324.2-324.25
  classification: 570.285
  related item:
    title info:
      title: Lecture notes in biomathematics ; 75
  identifier: 9783642456510 (electronic bk.)
  identifier: 3642456510 (electronic bk.)
  identifier: 9783540501534
  identifier: 3540501533
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: AU@
    record creation date: 120227
    record change date: 20260422173320.8
    record identifier: in00003575044
    language of cataloging:
      language term: eng