rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Advances in Down Syndrome Research
  name:
    name part: Lubec, G.
    role:
      role term: creator
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: au
    date issued: 2003
    issuance: monographic
  language:
    language term: eng
  physical description:
    reformatting quality: access
    form: remote
    extent: 1 online resource (x, 242 pages)
  abstract: "Advances in Down Syndrome Research" represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded structures including transcription factors are indeed overexpressed although findings in fetal DS are different from those in adult DS brain when Alzheimer-like neuropathology supervenes.
  note: edited by G. Lubec.
  note: Electronic resource.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Neurosciences
  subject:
    topic: Pathology
  subject:
    topic: Pediatrics
  subject:
    topic: Psychiatry
  subject:
    topic: Human genetics
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Pathology
  subject:
    topic: Pediatrics
  subject:
    topic: Psychiatry
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Journal of Neural Transmission Supplement 67 ; 67
  identifier: 9783709167212 (electronic bk.)
  identifier: 3709167213 (electronic bk.)
  identifier: 9783211407769
  identifier: 3211407766
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: AU@
    record creation date: 120608
    record change date: 20260422220746.5
    record identifier: in00003574299
    language of cataloging:
      language term: eng