Aging at the Molecular Level /

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and main...

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Bibliographic Details
Main Author:	Zglinicki, Thomas
Corporate Author:	SpringerLink (Online service)
Format:	eBook
Language:	English
Published:	Dordrecht : Springer Netherlands : Imprint: Springer, 2003.
Series:	Biology of aging and its modulation ; 1.
Subjects:	Life sciences. Human genetics. Dermatology. Biochemistry. Cytology. Morphology (Animals) Life Sciences. Cell Biology. Animal Anatomy / Morphology / Histology. Biochemistry, general. Human Genetics. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Editorial: About the series Biology of aging and its modulation". Preface
1. Free radical production and antioxidant defense: a primer
2. Oxidative DNA damage and repair implications for aging
3. Oxidative damage to proteins
4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies
5. Genomic instability in human premature aging
6. Oxidative damage, somatic mutations and cellular aging
7. Mitochondria and aging
8. Biological clocks in the aging cell
9. Telomeric damage in aging
10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice
11. Non-oxidative modification of DNA and proteins
12. Transcriptional and translational dysregulation during aging
13. Metabolic regulation of gene silencing and life span
14. The proteasome in aging
15. Aging and lysosomal degradation of cellular constituents
Index.