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P53 suppressor gene /

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This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by...

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Bibliographic Details
Main Author: Mukhopadhyay, Tapas
Corporate Author: SpringerLink (Online service)
Other Authors: Maxwell, Steven A., Roth, Jack A.
Format: eBook
Language:English
Published: New York : Springer-Verlag : R.G. Landes Co., [1995]
Series:Molecular biology intelligence unit (Unnumbered)
Subjects:
p53 antioncogene.
Cell Transformation, Neoplastic > genetics.
Genes, p53.
Gènes p53.
Transformation cellulaire néoplasique > Génétique.
Neoplasias.
Protein p53.
Suppressorgen.
Tumorsuppressor-Gen.
Electronic books.
Online Access:Connect to the full text of this electronic book
Description
Summary:This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.
Physical Description:1 online resource (129 pages)
Bibliography:Includes bibliographical references and index.
ISBN:9783662222751 (electronic bk.)
3662222752 (electronic bk.)