Immunobiology of Bacterial CpG-DNA /

Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules...

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Bibliographic Details
Main Author: Wagner, Hermann
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2000.
Series:Current topics in microbiology and immunology ; 247.
Subjects:
Online Access:Connect to the full text of this electronic book

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505 0 |a Mechanism of Action of CpG DNA -- Oligodeoxyribonucleotides with 5'-ACGT-3' or 5'-TCGA-3' Sequence Induced Production of Interferons -- Macrophage Activation by Immunostimulatory DNA -- Consequences of Bacterial CpG DNA-Driven Activation of Antigen-Presenting Cells -- Signal Transduction Pathways Activated by CpG-DNA -- CpG DNA Co-Stimulated Antigen-Reactive T Cells -- Role of Type I Interferons in T Cell Activation Induced by CpG DNA -- Hematopoietic Remodelling Triggered by CpG DNA -- CpG DNA Augments the Immunogenicity of Plasmid DNA Vaccines -- The Role of Bacterial DNA in Autoantibody Induction -- CpG DNA in Cancer Immunotherapy -- Use of CpG DNA for Enhancing Specific Immune Responses -- Immunostimulatory-Sequence DNA is an Effective Mucosal Adjuvant -- CpG DNA Switches on Th1 Immunity and Modulates Antigen-Presenting Cell Function -- Effects of CpG DNA on Th1/Th2 Balance in Asthma -- Responses of Human B Cells to DNA and Phosphorothiase Oligodeoxynucleotides. 
520 |a Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field. 
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