http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xii, 214 pages) : illustrations (some color).
This volume describes high-throughput approaches to a series of robust, established methodologies in molecular genetic studies of population samples. Such developments have been essential not only to linkage and association studies of single-gene and complex traits in humans, animals and plants, but also to the characterisation of clone banks, for example in mapping of genomes. Chapters have been written by developers or highly experienced end-users concerned with a diverse array of biological applications. The book should appeal to any researcher for whom costs and throughput in their genetics laboratory have become an issue.
1. Mapping Genes for Common Diseases: Statistical Planning, Power, Efficiency and Informatics / Andy Collins -- 2. Human DNA Sampling and Banking / Emmanuel Spanakis -- 3. Microsatellite Genotyping / Cheni Kwok and Karin Schmitt -- 4. Minisatellite and Microsatellite DNA Fingerprinting / Paul G. Debenham -- 5. Multiplex Polymerase Chain Reaction and Immobilized Probes: Application to Cardiovascular Disease / Suzanne Cheng -- 6. The Special Case of HLA Genes: Detection and Resolution of Multiple Polymorphic Sites in a Single Gene / W. Martin Howell and Katherine L. Poole -- 7. Microplate Array Diagonal Gel Electrophoresis (MADGE) Methodologies: The First Five Years / Ian N. M. Day, Emmanuel Spanakis and Lesley J. Hinks / [et al.] -- 8. The Use of Sequence Analysis for Homozygote and Heterozygote Base Variation Discovery / Hans-Ulrich Thomann, Michael FitzGerald and Heidi Giese / [et al.]
Includes bibliographical references and index.