rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: TOR
    sub title: Target of Rapamycin
  name:
    name part: Thomas, George.
    role:
      role term: creator
  name:
    name part: Sabatini, D. M. (David M.)
  name:
    name part: Hall, Michael N.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: gw
    date issued: 2004
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (x, 364 pages 49 illustrations, 2 illustrations in color.)
  abstract: TOR, the Target of Rapamycin was discovered a little over ten years ago in a genetic screen in S. cerevisiae in search of mutants resistant to the cytostatic effects of the anti-mycotic, rapamycin. Since that time orthologues have been identified in all eukaryotes examined to date, including humans. Recent studies have placed TOR at the interface between nutrient sensing and the regulation of major anabolic and catabolic responses. The significance of understanding the molecular mechanisms which control TOR function has been underscored by Phase 1 clinical trials, showing that rapamycin is not only therapeutically important as an immunosuppressive but is also efficacious in the treatment of solid tumors. Indeed, currently, homologues of rapamycin are in broad-based trials to determine its use in the treatment of other pathological conditions, such as inflammation and restenosis. Given these observations a great deal of attention has been drawn to TOR and its role cellular homoeostasis and human disease. Here we have gathered the leading figures in the field to summarize their own contributions to uncovering TOR function and to speculate where they think the field will be moving in the next few years.
  note: edited by George Thomas, David M. Sabatini, Michael N. Hall.
  note: Electronic resource.
  subject:
    topic: Medicine
  subject:
    topic: Microbiology
  subject:
    topic: Medicine
  subject:
    topic: Microbiology
  classification: QR46
  classification: 616.9041
  related item:
    title info:
      title: Current topics in microbiology and immunology ; 279
  identifier: 9783642189302 (electronic bk.)
  identifier: 364218930X (electronic bk.)
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: I9W
    record creation date: 121227
    record change date: 20260422155256.0
    record identifier: in00003553320
    language of cataloging:
      language term: eng