| Tag |
First Indicator |
Second Indicator |
Subfields |
| LEADER |
00000cam a2200000Ma 4500 |
| 001 |
in00003553313 |
| 006 |
m o d |
| 007 |
cr nn||||||||| |
| 008 |
121227s2004 gw a obf 001 0 eng d |
| 005 |
20260420201238.9 |
| 020 |
|
|
|a 9783642188916 (electronic bk.)
|
| 020 |
|
|
|a 3642188915 (electronic bk.)
|
| 035 |
|
|
|a (OCoLC)840291594
|
| 040 |
|
|
|a I9W
|b eng
|e pn
|c I9W
|d OCLCO
|d OCLCQ
|d KIJ
|d UV0
|d GW5XE
|d OCLCQ
|d UtOrBLW
|
| 049 |
|
|
|a TXAM
|
| 050 |
|
4 |
|a RM1-950
|
| 082 |
0 |
4 |
|a 615
|2 23
|
| 100 |
1 |
|
|a Holzer, Peter.
|
| 245 |
1 |
0 |
|a Tachykinins /
|c edited by Peter Holzer.
|
| 264 |
|
1 |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint :
|b Springer,
|c 2004.
|
| 300 |
|
|
|a 1 online resource (XII, 569 pages 62 illustrations, 6 illustrations in color.)
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Handbook of Experimental Pharmacology, 0171-2004 ;
|v 164
|
| 504 |
|
|
|a Includes bibliographical references and index.
|
| 505 |
0 |
|
|a Preface -- History of a Pioneering Neuropeptide: Substance P -- The Tachykinin Peptide Family, with Particular Emphasis on Mammalian Tachykinins and Tachykinin Receptor Agonists -- The Histochemistry of Tachykinin Systems in the Brain -- The Nomenclature of Tachykinin Receptors -- The Mechanism and Function of Agonist-Induced Trafficking of Tachykinin Receptors -- Tachykinin NK1 Receptor Antagonists -- Tachykinin NK2 Receptor Antagonists -- Tachykinin NK3 Receptor Antagonists -- Combined Tachykinin NK1, NK2, and NK3 Receptor Antagonists -- Pre-Protachykinin and Tachykinin Receptor Knockout Mice -- Therapeutic Potential of Tachykinin Receptor Antagonists in Depression and Anxiety Disorders -- Role of Tachykinins in Nausea and Emesis -- Substance P (NK1) Receptor Antagonists -- Analgesics or Not?- Role of Tachykinins in Neurogenic Inflammation of the Skin and Other External Surfaces -- Role of Tachykinins in Obstructive Airway Disease -- Role of Tachykinins in the Gastrointestinal Tract.
|
| 520 |
|
|
|a The tachykinins represent one of the most thoroughly investigated family of neuropeptides, whose members and receptors have been characterized at the genetic and molecular level and whose pharmacology has now been advanced to the first clinical application. These exciting accomplishments and prospects are reviewed and discussed in this volume in an authoritative manner. Particular emphasis is laid on the development of selective non-peptide antagonists for all 3 tachykinin receptors and their potential as novel drugs in a variety of diseases. The approval of the first tachykinin receptor antagonist as an antiemetic drug is particularly highlighted, and the utility of tachykinin receptor antagonists in affective disorders, chronic obstructive airway disease and irritable bowel syndrome, to name a few indications, is extensively considered.
|
| 500 |
|
|
|a Electronic resource.
|
| 650 |
|
0 |
|a Tachykinins
|x Agonists
|x Therapeutic use
|v Handbooks, manuals, etc.
|
| 650 |
|
0 |
|a Tachykinins
|x Antagonists
|x Therapeutic use
|v Handbooks, manuals, etc.
|
| 650 |
|
0 |
|a Tachykinins
|x Physiological effect
|v Handbooks, manuals, etc.
|
| 655 |
|
7 |
|a Electronic books.
|2 local
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 830 |
|
0 |
|a Handbook of experimental pharmacology ;
|v 164.
|
| 856 |
4 |
0 |
|u http://proxy.library.tamu.edu/login?url=https://link.springer.com/10.1007/978-3-642-18891-6
|z Connect to the full text of this electronic book
|t 0
|
| 994 |
|
|
|a 92
|b TXA
|
| 999 |
|
|
|a MARS
|
| 999 |
f |
f |
|s b7f6e7cc-7789-30f1-98be-5d122811e157
|i 1c07ec1e-420c-3c78-aff0-fecb77d29ea3
|t 0
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e RM1-950
|h Library of Congress classification
|
| 998 |
f |
f |
|a RM1-950
|t 0
|l Available Online
|