Antisense research and application /
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discuss...
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
Berlin ; New York :
Springer,
[1998]
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| Series: | Handbook of experimental pharmacology ;
v. 131. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Basic Principles of Antisense Therapeutics.-Antisense Medicinal Chemistry.-In vitro Cellular Uptake ...-Pharmaco- kinetic Properties ...-Toxocity of Ligodeoxynucleotide Therapeutic Agents.-Pharmacokinetic Properties of Phosphoro- thiotae Oligon.in Humans.-Safety and Tolerance of Phosh.in Humans.-Immune Stimulation by Oligon.-Pharmacological Inhibition of Dopaminergic and Other Neurotransmitter Receptors. Pharmacological Effects of Antisense Oligon. Inhibition of Immediate Early Response Genes in the DNS. Inhibition of G Proteins by Antisense Drugs.-Use of Antisense Oligon. to Modify Inflammatory Processes
- Antisense Oligon. and Their Anticancer Activities
- Pharmacological Activity of Antisense Oligon.in Animal Models of Disease.-Clinical Antiviral Activities.-Antisense Oligon.to Protein Kinase C-alpha and C-raf Kinase.-Nucleic Acid Therapeutics for Human Leukemia
- Properties of ISIS 2302.-Pharmacokinetics & Bioavailability of Oligon. Following Oral and Colorectal Admin.in Exp. Animals
- Antisense Properties of Peptide Nucleic Acid.-Triple Stranding Strategies and Progress.