Concepts in biochemical pharmacology /
| Corporate Author: | |
|---|---|
| Other Authors: | , , , , |
| Format: | eBook |
| Language: | English |
| Published: |
Berlin, New York :
Springer-Verlag,
1971-
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| Series: | Handbuch der experimentellen Pharmakologie. New series ;
v. XXVIII, 1. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Section one. Routes of drug administration. 1. Biological membranes and their passage by drugs ; 2. Absorption of drugs from the gastrointestinal tract ; 3. Buccal apsorption of drugs ; 4. Subcutaneous and intramuscular injection of drugs ; 5. Absorption, distribution and excretion of gaseous anesthetics ; 6. Aerosols ; 7. Absorption of drugs through the skin
- Section two. Sites of drug transport and disposition. 8. The nature of drug-protein interaction ; 9. Physical methods for studying drug-protein binding ; 10. Effect of binding to plasma proteins on the distribution, activity and elimination of drugs ; 11. Competition between drugs and normal substrates for plasma and tissue binding sites ; 12. Drug entry into brain and cerebrospinal fluid with ; 13. Translocation of drugs into bone ; 14. Translocation of drugs and other exogenous chemicals into adipose tissue ; 15. Placental transfer of drugs and their distribution in fetal tissues ; 16. The use of autoradiography in experimental pharmacology ; 17. Accumulation of drugs at sympathetic nerve endings
- Section three. Sites of drug excretion. 18. Excretion of drugs by the kidney ; 19. Excretion of drugs in bile ; 20. Excretion of drugs by milk ; 21. Extracorporeal and peritoneal dialysis of drugs
- Author index.
- Section four. Methods of studying the metabolism of drugs. Subsection A. Assay of drugs and their metabolites. 22. Basic principles in development of methods for drug assay. With 2 figures ; 23. Absorption spectrophotometry ; 24. Fluorometry. With 1 figure ; 25. Radioactive techniques: the use of labeled drugs. With 2 figures ; 26. Radioactive techniques: radioactive isotope derivatives of nonlabeled drugs ; 27. Gas chromatography. With 18 figures ; 28. Enzymatic assays in pharmacology. With 4 figures ; 29. Bioassay. With 2 figures ; 30. Immunoassay. With 2 figures
- Subsection B. Isolation and identification of drug metabolites. 31. Paper, column and thin layer chromatography, counter-current distribution and electrophoresis ; 32. Isotope dilution analysis. With 4 figures ; 33. Gas chromatography-mass spectrometry. With 8 figures ; 34. The application of various spectroscopies to the identification of drug metabolites. With 5 figures
- Section five. Sites of drug metabolism. 35. Introduction: pathways of drug metabolism. Subsection A. Microsomal enzymes. 36. Some morphological characteristics of hepatocyte endoplasmic reticulum and some relationships between endoplasmic reticulum, microsomes, and drug metabolism ; 37. Model systems in studies of the chemistry and the enzymatic activation of oxygen. With 9 figures ; 38. Cytochrome P-450 its function in the oxidative metabolism of drugs. With 23 figures ; 39. Enzymatic oxidation at carbon ; 40. N-oxidation enzymes. With 2 figures ; 41. Enzymatic N-, 0-, and S-dealkylation of foreign compounds by hepatic microsomes. With 4 figures ; 42. Reductive enzymes. With 6 figures ; 43. Oxidative desulfuration and dearylation of selected organophosphate insecticides ; 44. Metabolism of halogenated compounds. With 7 figures ; 45: Glucuronide-forming enzymes. With 1 figure ; 46. Metabolism of normal body constituents by drug-metabolizing enzymes in liver microsomes ; 47. Tissue distribution studies of polycyclic hydrocarbon hydroxylase activity ; 48. Mechanisms of induction of drug metabolism enzymes. With 9 figures ; 49. Inhibition of drug metabolism. With 1 figure
- Subsection B. Nonmicrosomal enzymes ; 50. Esterases of human tissues. With 2 figures ; 51. Enzymatic oxidation and reduction of alcohols, aldehydes and ketones ; 52. Amine oxidases ; 53. Sulphate conjugation enzymes. With 3 figures ; 54. Acetylating, deacetylating and amino acid conjugating enzymes. With 3 figures ; 55. Mercapturic acid conjugation. With 1 figure ; 56. Methyltransferase enzymes in the metabolism of physiologically active compounds and drugs ; 57. Enzymes that inactivate vasoactive peptides. With 2 figures ; 58. The metabolism of analogs of endogenous substrates: wider application of a limited concept. With 15 figures
- Author index.