rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Antimicrobial drug discovery
    sub title: emerging strategies
  name:
    name part: Mylonakis, Eleftherios
    role:
      role term: editor.
  name:
    name part: Tegos, George
    role:
      role term: editor.
  name:
    name part: C.A.B. International
    role:
      role term: issuing body.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    date issued: 2012
    copyright date: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (x, 357 pages) : illustrations, charts.
  abstract: This book, inclusive of 22 chapters, describes novel approaches currently used for antimicrobial drug discovery, focusing on agents for use against bacterial and fungal pathogens. Specific chapters discuss: (1) concepts relevant to drug resistance; (2) microbial mechanisms related to efflux pumps and studies on their potential inhibitors; (3) impact of multidrug tolerance of biofilms and persister cells; (4) bacterial quorum-sensing inhibition; (5) inhibition of the bacterial filamentous temperature-sensitive mutant Z (FtsZ); (6) antibacterial properties of lysostaphin; (7) strategies to identify modified ribosomally synthesized antimicrobials; (8) quantitative structure-activity relationship studies of novel antimicrobial peptides; (9) bacterial acetyl-CoA carboxylase and lipopolysacharide as drug targets for antibiotic development; (10) pathosystematic systems biology for the rational design of novel antifungal compounds; (11) specific animal models for novel antimicrobial discovery; and (12) new antimicrobial technology platforms such as antimicrobial photodynamic therapy and carbon nanotubes.
  table of contents: Emerging discovery strategies : an evolving necessity / Anthony R. Ball and George P. Tegos -- The antibiotic crisis / Arnold L. Demain and Jaroslav Spizek -- Structure, genetic regulation, physiology and function of the AcrAB-TolC efflux pump of escerichia coli and salmonella / Leonard Amaral ... [et al.] -- Small molecule efflux pump inhibitors from natural products as a potential source of antimicrobial agents / Sanjay M. Jachak ... [et al.] -- Fungal efflux-mediated resistance : from targets to inhibitors / Brian C. Monk ... [et al.] -- Vacuolar ATPase (V-ATPase) : a model proton pump for antifungal drug discovery -- Karlett J Parra -- Drug tolerance, persister cells and drug discovery / Kim Lewis -- Inhibition of quorum sensing as a novel antimicrobial strategy -- Gilles Brackman, Hans J. Nelis and Tom Coenye -- Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target / Jaroslaw M. Boberek ... [et al.] -- Lysostaphin : a silver bullet for staph / John F. Kokai-Kun -- Strategies to identify modified ribosomally synthesized antimicrobials -- Alan J. Marsh ... [et al.] -- QSAR based discovery of antimicrobial peptides active against multidrug resistant bacteria / Christopher D. Fjell ... [et al.] -- Acetyl-CoA carboxylase as a target for antibacterial development / Grover L. Waldrop -- Underexploited targets in LPS biogenenesis for the design of antibacterials / Laura Cipolla ... [et al.] -- Predicting and dissecting biomolecular interactions by information-driven docking / Panagiotis Kastritsis & Alexandre M.J.J Bonvin -- Anti-fungals and anti-fungal drug discovery / Richard Calderone ... [et al.] -- Pathosystematic studies and the rational design of antifungal interventions / Elaine M Bignell and Darius Armstrong-James -- In vivo high-throughput antimicrobial discovery screens utilizing caenorhabditis elegans as an alternative host / Jeffrey J. Coleman and Eleftherios Mylonakis -- Drosophila melanogaster as a versatile model for disco…
  note: edited by George Tegos, University of New Mexico, Department of Pathology, Center for Molecular Discovery, University of New Mexico Health Sciences, Albuquerque, USA and Eleftherios Mylonakis, Harvard Medical School, Massachusetts General Hospital, Division of Infectious Diseases, Boston, USA.
  note: Access limited to subscribing institution.
  note: Includes bibliographical references and index.
  subject:
    topic: Anti-Infective Agents
    topic: pharmacology
  subject:
    topic: Drug Design
  subject:
    topic: Disease Models, Animal
  subject:
    topic: High-Throughput Screening Assays
    topic: methods
  subject:
    topic: Photosensitizing Agents
    topic: pharmacology
  subject:
    topic: Anti-infective agents
    topic: Development
  subject:
    topic: Drug development
  subject:
    topic: Drug resistance
  subject:
    topic: Animal Models of Human Diseases, (New March 2000)
  subject:
    topic: Animal and in vitro Models for Pharmaceuticals, (New March 2000)
  subject:
    topic: Biochemistry and Physiology of Microorganisms, (New March 2000)
  subject:
    topic: Biosensors and Biological Nanotechnology, (New June 2002)
  subject:
    topic: Non-drug Therapy and Prophylaxis of Humans, (New March 2000)
  subject:
    topic: Prion, Viral, Bacterial and Fungal Pathogens of Humans, (New March 2000)
  subject:
    topic: Acetyl-CoA carboxylase
  subject:
    topic: Animal models
  subject:
    topic: Antibacterial agents
  subject:
    topic: Antifungal agents
  subject:
    topic: Bacteria
  subject:
    topic: Bacterial diseases
  subject:
    topic: Biofilms
  subject:
    topic: Disease models
  subject:
    topic: Drug development
  subject:
    topic: Drug resistance
  subject:
    topic: Drug susceptibility
  subject:
    topic: Drug targets
  subject:
    topic: Fungi
  subject:
    topic: Human diseases
  subject:
    topic: Laboratory animals
  subject:
    topic: Lipopolysaccharides
  subject:
    topic: Mycoses
  subject:
    topic: Peptide antibiotics
  subject:
    topic: Phototherapy
  subject:
    topic: Resistance mechanisms
  subject:
    topic: Structure activity relationships
  classification: RM267 .A554 2012eb
  classification: 615.7/92
  related item:
    title info:
      title: Antimicrobial drug discovery
    origin info:
      publisher: Wallingford, Oxfordshire : CABI, c2012.
    identifier: (DLC)2012001019
  related item:
    title info:
      title: Advances in molecular and cellular microbiology ; 22
  identifier: 9781845939434 (alk. paper)
  identifier: http://proxy.library.tamu.edu/login
  access condition: Access limited to subscribing institution.
  record info:
    record content source: CtWfDGI
    record creation date: 130731
    record change date: 20210304154800.0
    record identifier: in00003524879
    language of cataloging:
      language term: eng