Table of Contents:
  • Free radicals: generation and mechanisms of damage
  • Trevor Slater, free radical redox chemistry and antioxidants
  • Regulation of gene expression in adaptation to oxidative stress
  • Radiation-induced free radical reactions
  • Nitric oxide and related radicals
  • Mechanisms of oxidative cell damage
  • Lipid peroxidation
  • Lipid peroxidation in dividing cells
  • Formation and metabolism of the lipid peroxidation product 4-hydroxynonenal in liver and small intestine
  • DNA damage by reactive oxygen species
  • Inflammation and a mechanism of hydrogen peroxide cytotoxicity
  • Aging
  • Free radical theory of aging
  • Oxidative stress state in aging and longevity mechanisms
  • Maillard reaction and oxidative stress are interrelated stochastic mechanisms of aging.
  • (cont) Glycoxidation: a non enzymatic mechanisms of protein aging
  • Marker or mechanism: possible pro-oxidant reactions of radical-damaged proteins in aging and atherosclerosis, an age-related disease
  • Cancer
  • Carcinogenesis and free radicals
  • Derangements of cellular metabolism in the pre-malignant syndrome
  • Molecular mechanisms of oxidant carcinogenesis
  • Involvement of oxy-radicals in cancer cell killing and growth
  • Free radicals and active states of oxygen in human cancer due to environmental pollutants
  • Metabolic disorders
  • Hepatotoxicity of experimental hemochromatosis
  • Role of inducible cytochrome P450 in the liver toxicity of poly-halogenated aromatic compounds
  • CBrCl₃ toxicity in isolated rat hepatocytes.
  • (cont) Evidence for a possible role of lipid peroxidation in experimental liver fibrosis
  • Ethanol-inducible cytochrome P450 2E1. regulation, radical formation and toxicological importance
  • Free radical-induced impairment of liver glycosylation processes in ethanol intoxication
  • Oxidative damage and human alcoholic disease
  • Oxidised low density lipoproteins
  • Protein peroxides
  • In vitro approach to the study of inflammatory reactions in atherosclerosis
  • Antioxidants
  • Antioxidant defenses in eukaryotic cells
  • Electron paramagnetic resonance studies on flavonoid compounds
  • Antioxidant mechanisms of vitamin E and beta-carotene
  • Nuclear pool of glutathione in hepatocytes.
  • (cont) Phospholipid hydroperoxide glutathione peroxidase is the major selenoperoxidase in nuclei and mitochondria of rat testis
  • Medical applications of antioxidants
  • Free radicals and antioxidants in muscular and neurological diseases and disorders
  • Pharmaceutical intervention for the prevention of post-ischemic reperfusion injury
  • Metal-catalyzed free radical injuries in childhood
  • Effect of antioxidants on oxidative modification of human low density lipoproteins
  • Approaches to the therapy of glutathione deficiency
  • Utilization of oral glutathione.