http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Toll-like receptor family members and their ligands
1 online resource (vi, 192 pages) : illustrations.
The innate immune system is sometimes referred to as the "primitive" immune system. Perhaps this has dissuaded immunologists from analyzing it so energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisticated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due.
Evolution of the TIR, tolls and TLRs : functional inferences from computational biology / B. Beutler and M. Rehli -- Plant disease resistance : commonality and novelty in multicellular innate immunity / R. Fluhr and R.N. Kaplan-Levy -- Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily / L.A.J. O'Neill -- Toll receptors in Drosophila : a family of molecules regulating development and immunity / J.L. Imler and J.A. Hoffmann -- Toll-like receptors and their ligands / G.M. Barton and R. Medzhitov -- Toll-like receptor-5 and the innate immune response to bacterial flagellin / K.D. Smith and A. Ozinsky -- TLR4 as the mammalian endotoxin sensor / B. Beutler -- TLR2 : cellular sensor for microbial and endogenous molecular patterns / C.J. Kirschning and R.R. Schumann -- Bacterial CpG-DNA licenses TLR9 / S. Bauer and H. Wagner -- MyD88 as a bottle neck in toll/IL-1 signaling / O. Takeuchi and S. Akira -- Heat shock proteins as ligands of toll-like receptors / R.M. Vabulas, H. Wagner, and H. Schild.
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Includes bibliographical references and index.
Current topics in microbiology and immunology ; 270