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Heart rate as a determinant of cardiac function
basic mechanisms and clinical significance
1 online resource (viii, 275 pages) : illustrations
In a variety of cardiac diseases the influence of heart rate on cardiac function is altered and both heart rate and heart rate variability are of great relevance for the prognosis of cardiac patients. This book provides a summary of the current knowledge on the influence of heart rate on myocardial function and hemodynamics in non-failing and failing animal and human hearts. The subcellular and molecular alterations underlying the altered heart rate response in heart failure are discussed in detail. In addition, studies related to the impact of heart rate and heart rate variability on arrhythmogenesis and prognosis in patients with cardiac diseases are critically reviewed. Finally, the relevance of heart rate control by therapeutic interventions is also discussed. The book contains 19 different chapters written by well-known experts in this novel and clinically important field.
Regulation of heart rate -- Influence of stimulation frequency on subcellular systems -- Modulation of the force-frequency relation -- Relevance of heart rate on hemodynamics and energetics -- Prognostic relevance of heart rate -- Therapeutic relevance of heart rate control.
"In the Gargellen Conference 'Heart rate as a determinant of cardiac function, basic mechanisms and clinical significance' international experts were brought together to elaborate on the interrelation between heart rate and myocardial function"--Introduction.
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