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Molecular neuropharmacology : strategies and methods /

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The ability to clone large numbers of receptors and transporters for neurotransmitters, and then to produce specific mutations of these proteins, has yielded significant understanding of their pharmacological and functional properties, with still deeper insight obtainable through the application of...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Schousboe, Arne, Bräuner-Osborne, Hans
Format: eBook
Language:English
Published: Totowa, N.J. : Humana Press, [2004]
Subjects:
Neurotransmitter receptors.
Neuropharmacology.
Molecular pharmacology.
Neuropharmacology > methods.
Receptors, Neurotransmitter.
Neurotransmitter Agents.
Receptors, GABA.
Receptors, Glutamate.
Neurotransmetteurs > Récepteurs.
Neuropharmacologie.
Pharmacologie moléculaire.
MEDICAL > Pain Medicine.
MEDICAL > Psychiatry > Psychopharmacology.
Electronic books.
Online Access:Connect to the full text of this electronic book
Description
Summary:The ability to clone large numbers of receptors and transporters for neurotransmitters, and then to produce specific mutations of these proteins, has yielded significant understanding of their pharmacological and functional properties, with still deeper insight obtainable through the application of computational and medicinal chemistry. In Molecular Neuropharmacology: Strategies and Methods, leading neuroscience investigators combine advanced chemistry with molecular modeling to produce a powerful collection of cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. Information about x-ray crystallographic analyses is included whenever available. State-of-the-art and highly practical, Molecular Neuropharmacology: Strategies and Methods provides detailed accounts of the tools needed to understand how CNS neurons communicate and promises the development of novel therapeutic agents and strategies for many neurological diseases.
Item Description:Electronic resource.
Physical Description:1 online resource (xi, 271 pages) : illustrations (some color)
Format:Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Bibliography:Includes bibliographical references and index.
ISBN:9781592596720 (electronic bk.)
159259672X (electronic bk.)