http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xii, 428 pages) : illustrations.
In Cerebral Signal Transduction: From First to Fourth Messengers, Maarten E.A. Reith and a team of leading experts comprehensively review and synthesize the most recent advances in our understanding of the role of cerebral signaling in neuronal and cerebral function. The authors emphasize the functional role of the various signaling pathways in memory, apoptosis and degeneration, depression, and drug dependence in both health and diseases states. The signaling pathways discussed include cAMP/PKA, Ca2+/calmodulin-dependent protein kinase, DAG/PKG, and neurotrophic factor signaling cascades. By taking full advantage of the newfound ability to selectively remove, reduce, or enhance specific components of the signaling pathways, the investigators writing here illuminate the varied signaling cascades, their crosstalk, and the many possibilities for changes in gene expression underlying long-term changes in brain function. Cutting-edge and comprehensive, Cerebral Signal Transduction: From First to Fourth Messengers advances our understanding of the mechanistic underpinnings of complex behavioral processes and clinically relevant brain diseases. A major contribution to the development of the novel pharmacotherapeutics targeting downstream events in the cascade of second, third, and fourth messengers, it will serve experimental and clinical neuroscientists as today's best and most complete guide to neuronal signaling.
From first to fourth messengers in the brain : an overview / Maarten E.A. Reith -- Cellular and molecular mechanisms of learning and memory / Matthew Lattal, Ted Abel -- Signal transduction pathways in well-defined models of learning and memory : drosophila and honeybee / Uli Müller -- Protein kinase C signaling in learning and memory / Eddy A. Van der Zee [and others] -- Neurotransmitter receptor-G-protein-mediated signal transduction in Alzheimer's Disease / Richard F. Cowburn -- NO signaling pathway in the brain : neural injury, neurological disorders, and aggression / Masayuki Sasaki, Valina L. Dawson, Ted M. Dawson -- Cellular signaling pathways in neuronal apoptosis : role in neurodegeneration and Alzheimer's Disease / Carl W. Cotman, Haoyu Qian, Aileen J. Anderson -- Role of second messengers in neurodegeneration / Aase Frandsen, Jette Bisgaard Jensen, Arne Schousboe -- Molecular and cellular determinants of stress and antidepressant treatment / Ronald S. Duman -- Long-term bidirectional hormonal and neuroplastic responses to stress : implications for the treatment of depression / Robert M. Post [and others] -- Signal transduction abnormalities in bipolar affective disorder / Peter P. Li, Stavroula Andreopoulos, Jerry J. Warsh -- Messengers in opioid dependence : gene disruption studies / Rafael Maldonado, Olga Valverde -- 5-HT1B knockout mouse : an animal model of vulnerability to drugs of abuse / Kimberly Scearce-Levie, René Hen -- Regulation of dopamine transporter by phosphorylation and impact on cocaine action / Roxanne A. Vaughan -- Dopamine transporter mRNA in human brain : distribution and regulatory effects in autopsy studies of cocaine abusers / Deborah C. Mash [and others].
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
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Includes bibliographical references and index.