http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Neuro-immune interactions in neurologic and psychiatric disorders
1 online resource (xiv, 204 pages) : illustrations (some color).
This book arrives at the moment when the role of inflammatory processes in neurodegenerative disease, mental illness, and injury is starting to become more widely appreciated. As summarized in these chapters from some of the major laboratories in the field, not only can the brain interact actively with the immune system, but it can generate its own inflammatory responses to stress, certain diseases, and other insults. The contribution of cytokines and other inflammatory molecules to Alzheimer's disease is highlighted here, as is the key importance of the brains's own inflammatory cells, the microglia. Such studies in cell culture and in animal models clearly have the potential to influence clinical practice. The two-way communication between the brain and the immune system is emphasized by experiments showing that infection in peripheral tissues can cause dramatic changes in behavior of animals, while behavioral states such as severe depression can induce marked changes in immune function. These molecular and anatomical bases for such interactions are becoming understood, which will ultimately have therapeutic implications.
Organization of inflammatory processes in Alzheimer's disease / J. Rogers, Y. Shen -- Glial cytokines in neurodegenerative conditions / R.E. Mrak, J.G. Sheng, W.S.T. Griffin -- Contributions of the glial injury response to the multifactorial pathogenesis of Alzheimer's disease / L. Mucke [and others] -- Cytokine communication between neurons and glia and the pathogenesis of Alzheimer's disease / B. Cordell [and others] -- Glial hyperactivity during aging as a neuroinflammatory process / C.E. Finch [and others] -- Mechanistic and metaphorical connections between NF-kB and the secreted Alzheimer's [beta]-amyloid precursor protein / S.W. Barger [and others] -- Pathological and biochemical studies of chronic neuroinflammation may lead to therapies for Alzheimer's disease / G.L. Wenk, B. Hauss-Wegrzyniak, L.B. Willard -- Serotonine-immune interactions in major depression / K. Kubera, M. Maes -- Responses in the raphe-hippocampal serotonergic system during peripheral inflammation : putative role in sickness behaviour / J.M.H.M. Reul, A.C.E. Linthorst -- Neuronal control of the immune response in the central nervous system : from pathogenesis to therapy / H. Wekerle, A. Flügel, H. Neumann -- Regulation of cyclic AMP synthesis in microglial cells and possible role of cyclic AMP in neuroprotection / G. Levi -- Cytokine and anti-inflammatory drug effects on brain trauma and Alzheimer's disease pathology in transgenic mice / P.H. Patterson -- In vivo involvement of the cytokine LIF during lesion-induced renewal of olfactory sensory neurons in adult mouse / S. Bauer [and others] -- Neuroglial activation in the nervous system following injury : role of cytokines / G.W. Kreutzberg -- Sickness behavior : a neuroimmune-based response to infectious disease / R. Dantzer [and others] -- Central origin of IL-1[beta] produced during peripheral inflammation : role of meninges / B. Vernet-Der Garabedian [and others] -- Vitamin D, a hormone involved in the control of neuro-immune interactions in the brain / P. Brachet [and others].
P. Patterson, C. Kordon, Y. Christen, editors.
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Includes bibliographical references and index.
Research and perspectives in neurosciences