rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Nucleic acid therapeutics in cancer
  name:
    name part: Gewirtz, A. M. (Alan M.)
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2004
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (219 pages) : illustrations (some color).
  abstract: The development of effectively targeted and efficiently delivered nucleic acids promises important advances in the diagnosis and treatment of human malignancies. In Nucleic Acid Therapeutics in Cancer, leading researchers, academic physicians, and clinicians clearly and succinctly review the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting methods and specific clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically. Concise yet highly readable, Nucleic Acid Therapeutics in Cancer offers those who require a cutting-edge critical synthesis not only a state-of-the-art account of this promising field, but also an illuminating introduction to their emerging therapeutic uses.
  table of contents: Antisense methodology / Fritz Eckstein -- Nucleic acid therapeutics / Alan M. Gewirtz -- Targeted genome modification via triple helix formation / Faye A. Rogers and Peter M. Glazer -- Therapeutic applications of ribozymes / John J. Rossi -- Use of catalytic DNA in target validation and therapeutics / Lun-Quan Sun -- Targeted destruction of small, stable RNAs / David A. Dunbar and Susan J. Baserga -- Mechanism of action of antisense RNA in eukaryotic cells / Zuo Zhang and Gordon G. Carmichael -- The transport of oligonucleotides into cells / R.L. Juliano -- Peptide-mediated delivery of antisense oligonucleotides and related material / Eric Vivås, Jean Philippe Richard and Bernard Lebleu -- Molecular vectors for gene delivery to cancer cells / Guy Zuber [and others] -- Considerations on the design of antisense oligonucleotides / Rosel Kretschmer-Kazemi Far, Jens Warnecke and Georg Sczakiel -- Identification of hybridization accessible sequence in messenger RNA / Lida K. Gifford, Ponzy Lu, and Alan M. Gewirtz -- Nucleic acids as gene targeting therapeutics / Joanna B. Opalinska and Susan E. Shetzline -- LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen) / C.A. Stein [and others] -- Antisense protein kinase A-RI restores normal signal transduction signatures to inhibit tumor growth / Yoon S. Cho-Chung.
  note: edited by Alan M. Gewirtz.
  note: Papers from a conference held Apr. 2000 in Bryn Mawr, Pa.
  note: Electronic resource.
  note: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
  note: digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
  note: Includes bibliographical references and index.
  subject:
    topic: Antisense nucleic acids
    topic: Therapeutic use
  subject:
    topic: Cancer
    topic: Chemotherapy
  subject:
    topic: Neoplasms
    topic: therapy
    genre: Congresses
  subject:
    topic: Genetic Therapy
    topic: methods
    genre: Congresses
  subject:
    topic: Nucleic Acids
    topic: therapeutic use
    genre: Congresses
  subject:
    topic: Acides nucléiques antisens
    topic: Emploi en thérapeutique
  subject:
    topic: Cancer
    topic: Chimiothérapie
  subject:
    topic: MEDICAL
    topic: Oncology
  subject:
    topic: HEALTH & FITNESS
    topic: Diseases
    topic: Cancer
  subject:
    topic: Tumeurs
    topic: thérapie
  subject:
    topic: Thérapie génique
    topic: méthodes
  subject:
    topic: Acides nucléiques
    topic: usage thérapeutique
  subject:
    topic: Antisense nucleic acids
    topic: Therapeutic use
  subject:
    topic: Cancer
    topic: Chemotherapy
  subject:
    topic: Nucleic acid therapeutics
  classification: RC271.A69 N83 2004
  classification: 616.99/4061
  classification: 2004 F-381
  classification: QZ 267 N9638 2004
  related item:
    title info:
      title: Nucleic acid therapeutics in cancer
    origin info:
      publisher: Totowa, N.J. : Humana Press, ©2004
    identifier: (DLC) 2003025020
    identifier: (OCoLC)53477911
  related item:
    title info:
      title: Cancer drug discovery and development
  identifier: 1592597777 (electronic bk.)
  identifier: 9781592597772 (electronic bk.)
  identifier: 1588292584 (alk. paper)
  identifier: 9781588292582 (alk. paper)
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OCLCE
    record creation date: 100824
    record change date: 20260422171346.8
    record identifier: in00003505847
    language of cataloging:
      language term: eng