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Antifolate drugs in cancer therapy /

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In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, othe...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Jackman, Ann L.
Format: eBook
Language:English
Published: Totowa, N.J. : Humana Press, [1999]
Series:Cancer drug discovery and development.
Subjects:
Folic acid > Antagonists > Therapeutic use.
Cancer > Chemotherapy.
Antimetabolites > Therapeutic use.
Folic acid > Derivatives > Therapeutic use.
Folic Acid Antagonists > therapeutic use.
Neoplasms > drug therapy.
Cancer > Treatment.
Antifoliques > usage thérapeutique.
Tumeurs > Traitement médicamenteux.
Cancer > Chimiothérapie.
Antimétabolites > Emploi en thérapeutique.
Antifoliques > Emploi en thérapeutique.
Aufsatzsammlung.
Folate.
Krebs (Medizin)
Therapie.
Electronic books.
Online Access:Connect to the full text of this electronic book
Description
Summary:In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors, 5-fluorouracil, and the new generation of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. In addition, they review in depth the modulation of antifolate drugs, folate and antifolate transport mechanisms, polyglutamation, resistance, and drug combinations, as well as pharmacogenomics, pharmacodynamics, regulation of gene expression, and mechanisms of cell death. The wide and progressive scope of Antifolate Drugs in Cancer Therapy provides entr to exciting new avenues for future research, and constitutes a new standard reference for all basic scientists and clinicians engaged in cancer therapeutics.
Item Description:Electronic resource.
Physical Description:1 online resource (x, 456 pages) : illustrations.
Format:Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Bibliography:Includes bibliographical references and index.
ISBN:9781592597253 (electronic bk.)
1592597254 (electronic bk.)