DNA repair in cancer therapy /
Because of drug resistance, currently available anticancer therapies-drugs, radiotherapy, and other biological agents-have limited efficacy in treating cancer. In DNA Repair in Cancer Therapy, leading cancer researchers and oncologists comprehensively review the many recent developments in DNA repai...
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
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Totowa, N.J. :
Humana Press,
[2004]
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| Series: | Cancer drug discovery and development.
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Clinical resistance to alkylators: status and perspective
- Role of nonhomologous end-joining and recombinational DNA repair in resistance to nitrogen mustard and DNA crosslinking agents
- Repair of DNA interstrnad crosslinks produced by cancer chemotherapeutic drugs
- Chemosensitization to platinum-based anticancer drugs: current trends and future prospects
- Regulation of DNA repair and apoptosis by p53 and its impact on alkylating drug resistance of tumor cells
- Stress-activated signal transduction pathways in DNA damage response: implications for repair, arrest, and therapeutic interventions
- Overcoming resistance to alkylating agents by inhibitors of O⁶-alkylguanine-DNA alkyltransferase.
- Cellular protection against the antitumor drug bleomycin
- Potential role of PARP inhibitors in cancer treatment and cell death
- Relationship among DNA repair genes, cellular radiosensitivity, and the response of tumors and normal tissues to radiotherapy
- Strand-break repair and radiation resistance
- V(D)J recombination and DNA double-strand-break repair: from immune deficiency to tumorigenesis
- Inherited disorders of genomic instability and cancer susceptibility
- Role of BRCA1 and BRCA2 in DNA repair and potential impact on therapeutics
- Genetic variations in DNA repair: their implications in human cancer risk, prevention, and therapy.