rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Immunosuppressant analogs in neuroprotection
  name:
    name part: Borlongan, Cesario V.
  name:
    name part: Isacson, Ole.
  name:
    name part: Sanberg, Paul R.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2003
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xxvii, 378 pages) : illustrations (some color)
  abstract: In recent years there has been a growing recognition that such widely used immunosuppressant drugs as cyclosporin and FK-506 and their analogs-the neuroimmunophilins-possess significant neurotrophic and neuroprotective properties in addition to their beneficial effects for transplant patients. In Immunosuppressant Analogs in Neuroprotection, pioneers in the field and leading neuroscientists and clinicians working with these drugs survey the most recent scientific evidence showing how they evolved from being purely immunosuppressant "drugs" to neuroprotective "agents." These authorities focus on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. They discuss their efficacy and mechanisms of action in vitro and in vivo; using these models of CNS disease, they report laboratory studies with compelling clinical indications for Alzheimer's disease, Huntington's disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction. They also present novel hypotheses on the mechanisms of neuroprotection, ranging from the blockade of mitochondrial permeability transition pores to free radical scavenging to the inhibition of calcineurin. Authoritative and cutting-edge, Immunosuppressant Analogs in Neuroprotection demonstrates that CsA, FK-506, and the immunophilins exert neuroprotective effects on their own and will serve well as a new breed of neuroprotective agents for the treatment of neurological disorders.
  note: edited by Cesario V. Borlongan, Ole Isacson, Paul R. Sanberg ; foreword by Solomon H. Snyder and Bahman Aghdasi.
  note: Electronic resource.
  note: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
  note: digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
  note: Includes bibliographical references and index.
  subject:
    topic: Nervous system
    topic: Degeneration
    topic: Chemoprevention
  subject:
    topic: Immunosuppressive agents
  subject:
    topic: Neuropratective agents
  subject:
    topic: Nervous system
    topic: Regeneration
  subject:
    topic: Immunosuppressive Agents
    topic: therapeutic use
  subject:
    topic: Immunophilins
  subject:
    topic: Neuroprotective Agents
    topic: pharmacology
  subject:
    topic: HEALTH & FITNESS
    topic: Diseases
    topic: Nervous System (incl. Brain)
  subject:
    topic: MEDICAL
    topic: Neurology
  subject:
    topic: Immunsuppressivum
  subject:
    topic: Nervendegeneration
  classification: RC365 .I46 2003
  classification: 616.8/0651
  classification: 2003 B-316
  classification: QW 920 I326 2003
  classification: XI 6600
  related item:
    title info:
      title: Immunosuppressant analogs in neuroprotection
    origin info:
      publisher: Totowa, N.J. : Humana Press, ©2003
    identifier: (DLC) 2002190244
    identifier: (OCoLC)49221944
  identifier: 1592593151
  identifier: 9781592593156
  identifier: 0896039447
  identifier: 9780896039445
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OCLCE
    record creation date: 100628
    record change date: 20260423141914.7
    record identifier: in00003501475
    language of cataloging:
      language term: eng