rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Novel Methodology Towards the Indole Core and Iron-Catalyzed Electrophilic Hydroamination of Alkenes
  name:
    name part: Huehls, Christopher Bryan
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Yang, Jiong
    role:
      role term: thesis advisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Indole-containing structures and their generation still draw much attention because of their ubiquity in natural products, medicinal compounds, and organic materials. Given this prevalence, synthetic methods toward these structural motifs are numerous, each with a distinct set of advantages and disadvantages. One significant challenge is the generation of 3,3-disubstituted indolines that are frequently encountered in indole cores. The discovery, optimization, and scope of a C3-quaternary indolenine synthesis, as well as, efforts to expand the methodology for the generation of higher order indole-containing polycycles, will be discussed. This novel reactivity also lead to a generalized synthesis of α,β-unsaturated N-aryl ketonitrones which has few literature examples. A modest start to realizing the success of 3-substituted non-N-protected indoles as a Michael donor will also be explored. Green chemistry continues to play an important role in creating a sustainable world. At the core of green chemistry is the reduction or elimination of the use or generation of hazardous substances. Catalysis by definition is green by reduction; however, many of the catalytic systems utilize toxic metals that can hamper or cause further concerns with allowable limits on industrial scales. Iron catalyzed reactions seek to replace these toxic metals with a benign one that is also relatively cheap. Nitrogen containing compounds are an important feed stock for the pharmaceutical and other industries. The iron catalyzed intermolecular hydroamination of alkenes with electrophilic amines will be discussed. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/152597
  note: by Christopher Bryan Huehls.
  note: "Major Subject: Chemistry"
  note: Includes vita.
  note: Doctor of Philosophy Texas A & M University 2014 http://hdl.handle.net/1969.1/152597
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Chemistry
  subject:
    topic: Indole
  subject:
    topic: Indolenine
  subject:
    topic: Nitrone
  subject:
    topic: Pyrroloindoline
  subject:
    topic: Hydrocarbazole
  subject:
    topic: Conjugate addition
  subject:
    topic: Iron
  subject:
    topic: Amination
  subject:
    topic: Hydroamination
  identifier: http://hdl.handle.net/1969.1/152597
  record info:
    record content source: TXA
    record creation date: 150203
    record change date: 20151206125637.0
    record identifier: in00003500007
    language of cataloging:
      language term: eng