rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Comparison of Salivary and Serum Levels of Soluble Toll-Like Receptor 4 (TLR4) in Patients with Sjögren's Syndrome (SS), A Case
    sub title: Control Study
  name:
    name part: Blansett, Jonathan Andrew
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Rees, Terry
    role:
      role term: thesis advisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Sjögren's syndrome (SS) is an auto-immune (AI) mediated destruction of the major and minor salivary glands, and is the second most common AI disease in the United States. Typical treatment palliative in nature and no treatment is available that will reverse or halt the progression of the disease process. SS poses many dental problems for affected patients due to a loss of the protective effects of the saliva, resulting in increased caries incidence. However, whether SS patients are more at risk for periodontal disease is controversial. Periodontal disease is a gram-negative bacterial infection that may or may not elicit an immune response resulting in the destruction of the attachment apparatus of the teeth. Toll-like receptors (TLRs) are highly conserved pattern recognition receptors found throughout the body. TLR4 recognizes lipopolysaccharide (LPS) on gram negative bacteria, and is involved in mucosal immunity. Many in vitro studies have reported an increased expression of TLR4 in both SS and periodontal disease. Whether or not TLR4 is a contributor to the induction and/or progression of SS and/or periodontal disease is unknown. This cross-sectional study examined potential differences in concentration of TLR4 in serum and citric acid-stimulated saliva from patients with SS and healthy age-, sex-, and periodontal disease matched control patients. Salivary function was stimulated with 5.0 mLs of 2% citric acid, and whole saliva samples were obtained. Full-mouth clinical periodontal measurements were recorded from 21 SS patients and 22 control patients. Salivary and plasma TLR4 concentrations were determined by enzyme-linked immunoassays in 20 patients per study group. Collected data was statistically analyzed for its respective distribution. No statistical differences in age, body mass index (BMI), salivary TLR4 concentrations, or clinical periodontal measurements were evident between either group. Salivary flow rates were significantly lower (P<0.001) whereas pla…
  note: by Jonathan Andrew Blansett.
  note: "Major Subject: Oral Biology"
  note: Includes vita.
  note: Master of Science Texas A & M University 2014 http://hdl.handle.net/1969.1/152614
  note: Includes bibliographical references.
  note: Text (Thesis)
  subject:
    topic: Major Oral Biology
  subject:
    topic: Sjögren's Syndrome
  subject:
    topic: Toll-like receptors
  subject:
    topic: Periodontal disease
  subject:
    topic: Salivary biomarkers
  identifier: http://hdl.handle.net/1969.1/152614
  record info:
    record content source: TXA
    record creation date: 150210
    record change date: 20151206125741.0
    record identifier: in00003498530
    language of cataloging:
      language term: eng