Peptidomimetics in organic and medicinal chemistry : the art of transforming peptides in drugs /
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimet...
| Main Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Chichester, West Sussex :
Wiley,
2014.
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| Series: | Wiley Online Library.
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Summary: | "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- |
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| Physical Description: | 1 online resource (xix, 288 pages). |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 1118683846 (electronic bk.) 1119950600 (hardback) 1306546982 (MyiLibrary) 9781118683842 (electronic bk.) 9781119950608 (hardback) 9781306546980 (MyiLibrary) |
| DOI: | 10.1002/9781118683033 |