rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Modeling and Characterization of Lymphatic Vessels Using a Lumped Parameter Approach
  name:
    name part: Jamalian Ardakani, Seyedeh Samira
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Moore, James E.
    name part: Jr
    name part: 1964-
    role:
      role term: thesis advisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: The lymphatic system is responsible for several vital roles in human body, one of which is maintaining fluid and protein balance. There is no central pump in the lymphatic system and the transport of fluid against gravity and adverse pressure gradient is maintained by the extrinsic and intrinsic pumping mechanisms. Any disruption of the lymphatic system due to trauma or injury can lead to edema. There is no cure for lymphedema partly because the knowledge of the function of the lymphatic system is lacking. Thus, a well-developed model of the lymphatic system is crucial to improve our understanding of its function. Here we used a lumped parameter approach to model a chain of lymphangions in series. Equations of conservation of mass, conservation of momentum, and vessel wall force balance were solved for each lymphangion computationally. Due to the lack of knowledge of the parameters describing the system in the literature, more accurate measurements of these parameters should be pursued to advance the model. Because of the difficulty of the isolated vessel and in-situ experiments, we performed a parameter sensitivity analysis to determine the parameters that affect the system most strongly. Our results showed that more accurate estimations of active contractile force and physiologic features of lymphangions, such as length/diameter ratios, should be pursued in future experiments. Also further experiments are required to refine the valve behavior and valve parameters. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/148276
  note: by Seyedeh Samira Jamalian Ardakani.
  note: "Major Subject: Biomedical Engineering"
  note: Includes vita.
  note: Master of Science Texas A & M University 2012 http://hdl.handle.net/1969.1/148276
  note: Includes bibliographical references.
  note: Text (Thesis)
  subject:
    topic: Major Biomedical Engineering
  subject:
    topic: parameter sensitivity
  subject:
    topic: Lumped-parameter model
  subject:
    topic: lymph transport
  subject:
    topic: lymphangion
  subject:
    topic: lymphatic vessel
  subject:
    topic: lymphatic system
  identifier: http://hdl.handle.net/1969.1/148276
  record info:
    record content source: TXA
    record creation date: 131217
    record change date: 20151206090642.0
    record identifier: in00003423777
    language of cataloging:
      language term: eng