rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Measuring dementia of the alzheimer type more precisely
  name:
    name part: Lowe, Deborah Anne
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Balsis, Steve
    role:
      role term: thesis advisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (vi, 36 pages)
  abstract: Alzheimer's disease (AD) progressively impairs cognitive and functional abilities. Research on pharmacological treatment of AD is shifting to earlier forms of the disease, including preclinical stages. However, assessment methods traditionally used in clinical research may be inappropriate for these populations. The Alzheimer Disease Assessment Scale-cognitive (ADAS-cog), a commonly used cognitive battery in AD research, is most sensitive in the moderate range of cognitive impairment. It focuses on immediate recall and recognition aspects of memory rather than retention and delayed recall. As clinical trials for dementia continue to focus on prodromal stages of AD, instruments need to be retooled to focus on cognitive abilities more prone to change in the earliest stages of the disease. One such domain is delayed recall, which is differentially sensitive to decline in the earliest stages of AD. A supplemental delayed recall subtest for the ADAS-cog is commonly implemented, but we do not know precisely where along the spectrum of cognitive dysfunction this subtest yields incremental information beyond what is gained from the standard ADAS-cog. An item response theory (IRT) approach can analyze this in a psychometrically rigorous way. This study's aims are twofold: (1) to examine where along the AD spectrum the delayed recall subtest yields optimal information about cognitive dysfunction, and (2) to determine if adding delayed recall to the ADAS-cog can improve prediction of functional outcomes, specifically patients' ability to complete basic and instrumental activities of daily living. Results revealed differential functioning of ADAS-cog subtests across the dimension of cognitive impairment. The delayed recall subtest provided optimal information and increased the ADAS-cog's measurement precision in the relatively mild range of cognitive dysfunction. Moreover, the addition of delayed recall to the ADAS- cog, consistent with my hypothesis, increased covariation with…
  note: by Deborah Anne Lowe.
  note: "Major Subject: Psychology"
  note: Includes vita.
  note: Master of Science Texas A & M University 2012 http://hdl.handle.net/1969.1/148262
  note: Includes bibliographical references.
  note: Text (Thesis)
  subject:
    topic: Major Psychology
  subject:
    topic: Activities of daily living
  subject:
    topic: Item response theory
  subject:
    topic: Alzheimer's Disease Assessment Scale-cognitive
  subject:
    topic: Dementia of the Alzheimer type
  subject:
    topic: Alzheimer's disease
  identifier: http://hdl.handle.net/1969.1/148262
  record info:
    record content source: TXA
    record creation date: 131211
    record change date: 20151206090611.0
    record identifier: in00003420406
    language of cataloging:
      language term: eng