rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Chitosan and its derivatives as promising drug delivery carriers
  name:
    name part: Prabaharan, M.
    role:
      role term: creator
  name:
    name part: ebrary, Inc
  type of resource: text
  genre: abstract or summary
  genre: Electronic books.
  origin info:
    place:
      place term: nyu
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    reformatting quality: access
    form: remote
    extent: 1 online resource : illustrations
  abstract: Chitosan, a natural based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel drug delivery systems. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. Chemical modification of chitosan is useful for the association of bioactive molecules to the polymer and controlling the drug release profile. Chemical modification will introduce desired properties and enlarge the field of the potential applications of chitosan with the choice of various types of side chains. In this monograph, recent studies on the various types of chitosan microspheres are discussed from the viewpoint of drug delivery applications. Moreover, different types of chitosan derivatives developed as controlled drug delivery carriers and their preparation methods are discussed in detail. The modifications discussed here include amphiphilic chitosan derivatives, N-(aminoalkyl) chitosan, carboxymethyl chitosan, thiolated chitosans, phosphorylated chitosan, etc. Special emphasis has been given to the development of chitosan-based polyelectrolyte complexes, graft copolymerized chitosan and chitosan-based stimuli-responsive hydrogels as drug delivery carriers. The reviewed studies lead to the conclusion that chitosan derivatives are promising materials for the controlled delivery of various types of therapeutic agents.
  table of contents: 1. Introduction --
  table of contents: 2. Sources of chitosan --
  table of contents: 3. Advantages of chitosan as drug delivery systems -- 3.1 Biocompatibility and biodegradability -- 3.2 pH sensitivity -- 3.3 Controlled drug release properties -- 3.4 Mucoadhesive properties -- 3.5 Permeation enhancing properties -- 3.6 Transfection enhancing properties -- 3.7 Gelling properties -- 3.8 Colon targeting properties -- 3.9 Ease of chemical modification --
  table of contents: 4. Chitosan-based drug delivery systems -- 4.1 Chitosan microspheres -- 4.1.1 Covalently crosslinked particles -- 4.1.2 Ionically crosslinked particles -- 4.2 Chemically modified chitosan -- 4.2.1 Amphiphilic chitosan derivatives -- 4.2.2 N-(aminoalkyl) chitosan -- 4.2.3 Succinyl, quateraminated and octanoyl chitosan -- 4.2.4 Carboxymethyl chitosan -- 4.2.5 Mitomycin-C conjugated N-succinyl-chitosan -- 4.2.6 Thiolated chitosans -- 4.2.7 Phosphorylated chitosan -- 4.2.8 Chitosan-based polyelectrolyte complexes -- 4.3 Graft Copolymerized chitosan -- 4.3.1 Chitosan-graft-poly(acrylic acid) -- 4.3.2 Chitosan-graft-poly(acrylamide) -- 4.3.3 Chitosan-graft-poly(methyl methacrylate) -- 4.3.4 Chitosan-graft-2-hydroxyethyl methacrylate -- 4.3.5 Chitosan-graft-poly(vinyl alcohol) -- 4.3.6 Chitosan-graft-poly(ethylene glycol) -- 4.3.7 Cyclodextrin grafted chitosan -- 4.3.8 Chitosan-graft-b-glycerophosphate -- 4.4 Chitosan-based stimuli-responsive hydrogels -- 4.5 Chitosan-ligand conjugates for active target drug delivery -- 4.5.1 Chitosan-sugar conjugates -- 4.5.2 Chitosan-folate conjugates -- 4.5.3 Chitosan-protein conjugates --
  table of contents: 5. Conclusions -- References.
  target audience: specialized
  note: M. Prabaharan.
  note: Electronic resource.
  note: Restricted to libraries which purchase an unrestricted PDF download via an IP.
  note: Also available in print.
  note: Mode of access: World Wide Web.
  note: System requirements: Adobe Acrobat reader.
  note: Includes bibliographical references (pages [61]-76).
  subject:
    topic: Chitosan
    topic: Biotechnology
  subject:
    topic: Polymeric drug delivery systems
  subject:
    topic: biomedical and materials engineers
  classification: TP248.65.C55 P723 2012
  classification: 610.28
  related item:
    title info:
      title: Biomedical & nanomedical technologies
  identifier: 9781606504130 (electronic bk.)
  identifier: 9781606504239 (print)
  identifier: https://ebookcentral.proquest.com/lib/tamucs/detail.action
  related item:
    location:
      url: https://ebookcentral.proquest.com/lib/tamucs/detail.action
  access condition: Restricted to libraries which purchase an unrestricted PDF download via an IP.
  record info:
    record content source: CaBNVSL
    record creation date: 130127
    record change date: 20250816223011.7
    record identifier: in00002814806