Microfabricated optical sensor probe for the detection of esophageal cancer /

Bibliographic Details
Main Author: Chinna Balareddy, Karthik Reddy
Other Authors: Zou, Jun (Thesis advisor)
Format: Thesis eBook
Language:English
Published: [College Station, Tex.] : [Texas A&M University], [2012]
Subjects:
Online Access:Link to OAK Trust copy

MARC

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099 |a 2009  |a Thesis  |a 1969.1/ETD-TAMU-2009-05-626 
100 1 |a Chinna Balareddy, Karthik Reddy. 
245 1 0 |a Microfabricated optical sensor probe for the detection of esophageal cancer /  |c by Karthik Reddy Chinna Balareddy. 
264 1 |a [College Station, Tex.] :  |b [Texas A&M University],  |c [2012] 
300 |a 1 online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
500 |a "Major Subject: Electrical Engineering" 
588 |a Description from author supplied metadata (automated record created 2012-10-22 13:24:58). 
502 |b Master of Science  |c Texas A&M University  |d 2009  |o http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-626 
504 |a Includes bibliographical references. 
516 |a Text (Thesis) 
520 3 |a Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society cancer causes accounts for 13% of all deaths. Much of the time cancer can be treated if diagnosed early. Considerable study is currently being undertaken to investigate tissue properties and their use in detecting cancer at an early stage through non invasive and non surgical methods. Oblique Incidence Diffuse Reflectance Spectrometry (OIDRS) is one such method. This thesis reports the design, fabrication and testing of a new miniaturized optical sensor probe with "side viewing" capability for oblique incidence diffuse reflectance spectrometry. The sensor probe consists of a lithographically patterned polymer waveguides chip and three micromachined positioning substrates and source/collection fibers to achieve 45 degree light incidence and collection of spatially resolved diffuse reflectance. The probe was tested at the Mayo Clinic in Rochester Minnesota. The test results show that the probe is capable of collecting data which can be analyzed to select image features to differentiate the cancerous tissue from non cancerous tissue. Using these probes, diffuse reflectance of human esophageal surface has been successfully measured for differentiation of cancerous tissues from normal ones. 
500 |a Electronic resource. 
650 4 |a Major Electrical Engineering. 
653 |a Microfabrication 
653 |a Oblique Incidence Diffuse Reflectance 
653 |a Micromachining 
700 1 |a Zou, Jun,  |e thesis advisor. 
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