Comparative performance analysis of the algorithms for detecting periodically expressed genes /

Bibliographic Details
Main Author: Agyepong, Kwadwo
Other Authors: Dougherty, Edward R. (Thesis advisor), Serpedin, Erchin (Thesis advisor)
Format: Thesis eBook
Language:English
Published: [College Station, Tex.] : [Texas A&M University], [2012]
Subjects:
Online Access:Link to OAK Trust copy

MARC

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099 |a 2012  |a Thesis  |a 1969.1/ETD-TAMU-2012-08-10815 
100 1 |a Agyepong, Kwadwo. 
245 1 0 |a Comparative performance analysis of the algorithms for detecting periodically expressed genes /  |c by Kwadwo Agyepong. 
264 1 |a [College Station, Tex.] :  |b [Texas A&M University],  |c [2012] 
300 |a 1 online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
500 |a "Major Subject: Electrical Engineering" 
588 |a Description from author supplied metadata (automated record created 2012-10-22 13:24:58). 
502 |b Master of Science  |c Texas A&M University  |d 2012  |o http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-10815 
504 |a Includes bibliographical references. 
516 |a Text (Thesis) 
520 3 |a Thus far, a plethora of analysis on genome-wide gene expression microarray experiments on the cell cycle have been reported. Time series data from these experiments include gene expression profiles that might be periodically expressed. However, the numbers and actual genes that are periodically expressed have not been reported with consistency, analysis on similar experiments reports disparate numbers of genes that are periodically expressed with scant overlap. This work ultimately compares the performance of five spectral estimation schemes in their ability to recover periodically expressed genes profiles. Lomb-Scargle (LS), Capon, Missing-Data Amplitude and Phase Estimation (MAPES), Real Value Iterative Adaptive Approach (RIAA) and Lomb-Scargle Periodogram Regression (LSPR) are rigorously studied and pitted against each other in various simulated testing conditions. Results obtained using synthetic and microarray data reveals that RIAA is an efficient and robust method for the detection of periodically expressed genes in short time series data that might be characterized with noisy and irregularly sampled data points. 
500 |a Electronic resource. 
650 4 |a Major Electrical Engineering. 
653 |a MAPES 
653 |a Time Series 
653 |a Cell Cycle 
653 |a Microarray 
653 |a LSPR 
653 |a RIAA 
653 |a Capon 
653 |a Lomb-Scargle 
700 1 |a Dougherty, Edward R.,  |e thesis advisor. 
700 1 |a Serpedin, Erchin,  |e thesis advisor. 
856 4 0 |u http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-10815  |z Link to OAK Trust copy  |t 0 
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998 f f |a 2012 Thesis 1969.1/ETD-TAMU-2012-08-10815  |t 0  |l Available Online