Bioisosteres in medicinal chemistry /
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first...
| Other Authors: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Weinhem :
John Wiley & Sons,
2012.
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| Series: | Methods and principles in medicinal chemistry ;
v. 54. Wiley Online Library. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Summary: | Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section. |
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| Item Description: | Electronic resource. |
| Physical Description: | 1 online resource (xviii, 237 pages :) : illustrations |
| ISBN: | 3527654305 (electronic bk.) 352765433X (electronic bk.) 9783527654307 (electronic bk.) 9783527654338 (electronic bk.) |
| DOI: | 10.1002/9783527654307 |