rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: A
    title: cholinergic sensory-motor circuit controls the male copulation behavior in C. elegans
  name:
    name part: Liu, Yishi.
    role:
      role term: creator
  name:
    name part: Garcia, Luis Rene
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: The nervous system coordinates a sequence of muscle movements to give rise to animal behaviors. In complex invertebrates or lab-studied vertebrates, due to the large number of cells in their nervous systems and the complexities of their behaviors, it is difficult to address how circuits process information to direct each motor output of the behavior. In this dissertation, I used the Caenorhabditis elegans male copulation behavior as a model to address how a compact circuit coordinates different behavioral programs. Insertion of a male copulatory organ into a suitable mate is a conserved and necessary behavioral step for most terrestrial mating. However, the detailed molecular and cellular mechanisms for this distinct social interaction have not been elucidated in any animal. During mating, the C. elegans male cloaca is positioned over the hermaphrodite̕ s vulva as he attempts to insert his copulatory spicules repetitively. Rhythmic spicule thrusts cease when insertion is sensed. Circuit components consisting of sensory/motor neurons and sex muscles for these steps have been previously identified, but it was unclear how their outputs are integrated to generate a coordinated behavior. Here, I delineate cellular and molecular mechanisms that transduce sensory information into coordinated behavioral programs during male mating.I show that contraction of the male oblique muscles is required to sustain genital contact between the sexes. These muscles are innervated by the postcloacal sensilla (p.c.s.) sensory/motor neurons. The ionotropic AChRs that contain either the ACR-16 or the UNC-29 subunit mediate synaptic transmission at these neuromuscular junctions; and a Gαq-coupled muscarinic AChR, GAR-3, is likely to function presynaptically to enhance the ionotropic AChRs-mediated synaptic transmission. For spicules to rhythmically thrust during genital contact, activity of the oblique muscles and the gubernacular muscles is transmitted to the spicule protractor muscles inst…
  note: by Yishi Liu.
  note: "Major Subject: Biology"
  note: Electronic resource.
  note: Doctor of Philosophy Texas A&M University 2011 http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9187
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Biology
  subject:
    topic: Cholinergic
  subject:
    topic: Male mating
  subject:
    topic: Gap junction
  subject:
    topic: C. elegans
  subject:
    topic: Behavior
  identifier: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9187
  record info:
    record content source: TXA
    record creation date: 120813
    record change date: 20150922111021.0
    record identifier: in00002773479