rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Comparative pathophysiology and toxicology of cyclooxygenases
  name:
    name part: Radi, Zaher A.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: nju
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xii, 324 pages) : illustrations
  abstract: The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks. Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing, COX inhibitors and renal system pathophysiology and mechanisms of toxicity, The pathophysiologic role of COX inhibition in the ocular system, COX inhibition and the respiratory and cardiovascular systems. The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.
  note: Zaher A. Radi.
  note: Electronic resource.
  note: Includes bibliographical references and index.
  subject:
    topic: Cyclooxygenases
    topic: Pathophysiology
  subject:
    topic: Cyclooxygenases
    topic: Toxicology
  subject:
    topic: MEDICAL / Toxicology
  classification: RA1242.D46 .R33 2012eb
  classification: 615.9/5137
  related item:
    identifier: (DLC) 2012002908
  related item:
    title info:
      title: Wiley Online Library
  identifier: 1118351886 (electronic bk.)
  identifier: 1118351916 (electronic bk.)
  identifier: 6613888524
  identifier: 9781118351888 (electronic bk.)
  identifier: 9781118351918 (electronic bk.)
  identifier: 9786613888525
  identifier: 0470577541 (Cloth)
  identifier: 9780470577547 (Cloth)
  identifier: 388852 MIL
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: CDX
    record creation date: 120229
    record change date: 20210728124937.0
    record identifier: in00002762456