rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: A
    title: model for blood coagulation and lysis utilizing the intrinsic and extrinsic pathways
  name:
    name part: Lacroix, Daniel Edward.
    role:
      role term: creator
  name:
    name part: Rajagopal, Kumbakonam R.
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Blood is a complex mixture of formed cellular elements, proteins, and ions dissolved in a solution. It is a difficult fluid to model because it is a shear-thinning, viscoelastic fluid that stress- relaxes. In this study, a new mathematical model for whole blood is developed from a general equation for a fluid with a shear dependent viscosity. The model is then used as a backdrop for 28 different biochemical factors interacting to form a clot. The full intrinsic and extrinsic pathways are both used in the simulation; the inclusion of the full intrinsic pathway is something that had not been done prior to this work. The model is executed in one spatial direction in an infinite domain as well as within a rigid walled cylinder using a finite volume scheme. The rigid wall, similar to the new mathematical equation for blood, is an oversimplification of actual in-vitro conditions. The results of both simulations show the formation and dissolution of the clot. Sensitivity analysis is then performed in the finite domain model by adjusting the initial levels of factors Va and Xa. The results show that by increasing the initial level of one or both of these factors leads to the quicker formation of a clot.
  note: by Daniel Edward Lacroix.
  note: "Major Subject: Mechanical Engineering"
  note: Electronic resource.
  note: Doctor of Philosophy Texas A&M University 2011 http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9494
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Mechanical Engineering
  subject:
    topic: mathematical model
  subject:
    topic: blood coagulation
  subject:
    topic: intrinsic pathway
  identifier: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9494
  record info:
    record content source: TXA
    record creation date: 120803
    record change date: 20150922105026.0
    record identifier: in00002756810