rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Salmonella infection on Arabidopsis seedlings requires both host and pathogen factors
  name:
    name part: Zhang, Yulan.
    role:
      role term: creator
  name:
    name part: Shan, Libo
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Human enteric pathogen Salmonella contaminates raw produce and triggers significant economic loss and illness. Under a natural environment, Salmonella resides in soil and enters the interior of plants without causing disease or eliciting symbiotic growth. Upon being consumed by humans, complex virulence mechanisms are elicited by the specific intestine conditions, such as high temperature and humidity and lead to profound infection. The lack of effective prevention and drug treatment are largely attributed to the unclear mechanistic understanding on Salmonella association with environmental media, and in vivo host and pathogen factors required for persistent infection. We have explored the potential of deploying the model plant organism Arabidopsis thaliana to tackle this fundamental yet clinically challenging question, as Arabidopsis possesses many advantages as a model system, including enriched genomic resources, powerful genetic tools, low maintenance cost and a large collection of individual gene deletion mutants. Our preliminary data demonstrated Arabidopsis seedlings under liquid culture conditions mimicking the intestine environment were infected and killed by salmonella within 2 days upon inoculation. The Arabidopsis system possesses well-developed genetic information and the resources to study host factors required for infection on very short time scales, thus complementing traditional animal genetic studies. We aim to define the pathogen factors required for this infection. By merging the fields of extremely powerful Arabidopsis genetics and bacterial genetics/genomics, we hope to provide insight into possible new paradigms for addressing salmonella-mediated food born infection.
  note: by Yulan Zhang.
  note: "Major Subject: Plant Pathology"
  note: Electronic resource.
  note: Master of Science Texas A&M University 2010 http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8934
  note: Includes bibliographical references.
  note: Text (Thesis)
  subject:
    topic: Major Plant Pathology
  subject:
    topic: Arabidopsis
  subject:
    topic: factor
  subject:
    topic: Salmonella
  subject:
    topic: infection
  identifier: http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8934
  record info:
    record content source: TXA
    record creation date: 120312
    record change date: 20151202151727.0
    record identifier: in00002741667