rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mitigating disuse bone loss
    sub title: role of resistance exercise and beta-adrenergic signaling
  name:
    name part: Swift, Joshua Michael.
    role:
      role term: creator
  name:
    name part: Bloomfield, Susan A.
    role:
      role term: thesis advisor.
  name:
    name part: Hogan, Harry A.
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Mechanical loading is an integral component to maintaining bone mass during periods of disuse (i.e. bedrest or casting) or reduced weightbearing activity. Recent data has shown a direct relation between the sympathetic nervous system (SNS) and bone metabolism, however the underlying mechanisms responsible for this relationship are unknown. Furthermore, the role that beta adrenergic stimulation during disuse has on cancellous bone mass and microarchitecture have yet to be defined. The central hypothesis of this research is that resistance exercise and beta-1 adrenergic (Adrb1) receptor agonist administration attenuate disuse-associated reductions in metaphyseal bone during 28 days of rodent hindlimb unloading (HU). Study one determined whether an eccentric- (ECC) or combined isometric+eccentric- (ISO+ECC) based contraction paradigm, engaged during hindlimb unloading (HU), mitigates losses in musculoskeletal mass and strength. Both simulated resistance training (SRT) protocols inhibited reductions in disuse-sensitive cancellous bone mass and maintained plantarflexor muscle strength. Study two determined whether combining the anabolic effects of SRT with the anti-resorptive effects of alendronate (ALEN) during HU positively impacts cancellous bone in an additive or synergistic fashion. ALEN significantly inhibited the anabolic response of cancellous bone to SRT during HU. Study three determined whether an Adrb1 receptor agonist (dobutamine; DOB) mitigates disuse-associated losses in bone mass and formation rate (BFR) during HU. DOB administration significantly blunted reductions in bone mineral density (vBMD) by maintaining cancellous BFR. Study four determined if Adrb1 receptor agonist administration during HU results in an attenuation of osteocyte apoptosis within cancellous bone and whether this relates to a decrease in Bax/Bcl-2 mRNA content ratio (pro- and anti-apoptotic proteins). HU significantly increased cancellous bone osteocyte apoptosis and Bax/Bcl-2 mRNA c…
  note: by Joshua Michael Swift.
  note: "Major Subject: Kinesiology"
  note: Title from author supplied metadata (automated record created 2011-08-09 15:09:44).
  note: Electronic resource.
  note: Doctor of Philosophy Texas A&M University 2010 http://hdl.handle.net/1969.1/ETD-TAMU-2010-05-7941
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major kinesiology
  subject:
    topic: apoptosis
  subject:
    topic: osteoblast
  subject:
    topic: mechanical loading
  subject:
    topic: rodent
  subject:
    topic: osteocyte
  subject:
    topic: unloading
  subject:
    topic: histomorphometry
  identifier: http://hdl.handle.net/1969.1/ETD-TAMU-2010-05-7941
  record info:
    record content source: TXA
    record creation date: 110819
    record change date: 20151202142324.0
    record identifier: in00002711592