Dosimetry of ⁹⁰Y liquid brachytherapy in a dog with osteosarcoma using PET/CT /
| Main Author: | |
|---|---|
| Other Authors: | , |
| Format: | Thesis eBook |
| Language: | English |
| Published: |
[College Station, Tex.] :
[Texas A&M University],
[2011]
|
| Subjects: | |
| Online Access: | Link to OAK Trust copy |
| Abstract: | A novel ⁹⁰Y liquid brachytherapy strategy is currently being studied for the treatment of osteosarcoma using a preclinical translational model in dogs to assess its potential efficacy and toxicity. In this study, dosimetry calculations are performed for ⁹⁰Y liquid brachytherapy in a dog with osteosarcoma using the Geant4 Monte Carlo code. A total of 611.83 MBq ⁹⁰Y radiopharmaceutical is administered via direct injections, and the in vivo distribution of ⁹⁰Y is assessed using a time-of-flight (TOF) PET/CT scanner. A patient-specific geometry is built using anatomical data obtained from CT images. The material properties of tumor and surrounding tissues are calculated based on a CT number - electron density calibration. The ⁹⁰Y distribution is sampled in Geant4 from PET images using a collapsing 3-D rejection technique to determine the decay sites. Dose distributions in the tumor bed and surrounding tissues are calculated demonstrating significant heterogeneity with multiple hot spots at the injection sites. Dose volume histograms show about 33.9 percent of bone and tumor and 70.2 percent of bone marrow and trabecular bone receive a total dose over 200 Gy; about 3.2 percent of bone and tumor and 31.0 percent of bone marrow and trabecular bone receive a total dose of over 1000 Gy. ⁹⁰Y liquid brachytherapy has the potential to be used as an adjuvant therapy or for palliation purposes. Future work includes evaluation of pharmacokinetics of the ⁹⁰Y radiopharmaceutical, calibration of PET/CT scanners for the direct quantitative assessment of ⁹⁰Y activity concentration, and assessment of efficacy of the ⁹⁰Y liquid brachytherapy strategy. |
|---|---|
| Item Description: | "Major Subject: Health Physics" Title from author supplied metadata (automated record created 2011-08-09 15:09:44). Electronic resource. |
| Physical Description: | 1 online resource. |
| Bibliography: | Includes bibliographical references. |