rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Transmission genetics of pancreatic acinar atrophy in the German Shepherd Dog and development of microsatellite DNA-based tools for canine forensics and linkage analysis
  name:
    name part: Clark, Leigh Anne.
    role:
      role term: creator
  name:
    name part: Murphy, Keith E.
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2004
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: The domestic dog, Canis lupus familiaris, has emerged as a model system for the study of human hereditary diseases. Of the approximately 450 hereditary diseases described in the dog, half have clinical presentations that are quite similar to specific human diseases. Understanding the genetic bases of canine hereditary diseases will not only complement comparative genetics studies but also facilitate selective breeding practices to reduce incidences in the dog. Whole genome screens have great potential to identify the marker(s) that segregate with canine hereditary diseases for which no reasonable candidate genes exist. The Minimal Screening Set-1 (MSS-1) was the first set of microsatellite markers described for linkage analysis in the dog and was, until recently, the best tool for genome screens. The MSS-2 is the most recently described screening set and offers increased density and more polymorphic markers. The first objective of this work was to develop tools to streamline genomic analyses in the study of canine hereditary diseases. This was achieved through the development of 1) multiplexing strategies for the MSS-1, 2) a multiplex of microsatellite markers for use in canine forensics and parentage assays and 3) chromosome-specific multiplex panels for the MSS-2. Multiplexing is the simultaneous amplification and analysis of markers and significantly reduces the expense and time required to collect genotype information. Pancreatic acinar atrophy (PAA) is a disease characterized by the degeneration of acinar cells of the exocrine pancreas and is the most important cause of exocrine pancreatic insufficiency (EPI) in the German Shepherd Dog (GSD). Although the prognosis for dogs having EPI is typically good with treatment, many dogs are euthanized because the owners are unable to afford the expensive enzyme supplements. The second objective of this work was to determine the mode of transmission of EPI in the GSD and conduct a whole genome screen for linkage. Two ext…
  note: by Leigh Anne Clark.
  note: "Major Subject: Veterinary Microbiology"
  note: Title from author supplied metadata (record created on Nov. 30, 2005.)
  note: Vita.
  note: Abstract.
  note: Electronic resource.
  note: System requirements: Adobe Acrobat Reader.
  note: Ph. D. Texas A&M University 2004
  note: Includes bibliographical references.
  note: Text (Dissertation).
  subject:
    topic: Major veterinary microbiology
  subject:
    topic: pancreatic acinar atrophy
  subject:
    topic: microsatellite
  subject:
    topic: hereditary diseases
  subject:
    topic: forensics
  subject:
    topic: linkage
  subject:
    topic: canine genetics
  identifier: http://hdl.handle.net/1969.1/439
  record info:
    record content source: TXA
    record creation date: 110308
    record change date: 20151202115710.0
    record identifier: in00002659330