http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Current trends in monoclonal antibody development and manufacturing
American Association of Pharmaceutical Scientists
xiv, 351 pages : illustrations (some color) ; 27 cm.
1. Introduction / Wayne R. Gombotz and Steven J. Shire -- pt. I. Design of therapeutic MABS. 2. CDR repair: a novel approach to antibody humanization / Mark S. Dennis -- 3. Nanobodies, single-domain antigen-binding fragments of camelid heavy-chain antibodies / Gholamreza Hassanzadeh Ghassabeh, Serge Muyldermans, and Dirk Saerens -- pt. II. Expression and production of MABS. 4. GPEx® a flexible method for the rapid generation of stable, high expressing, antibody producing mammalian cells lines / Gregory T. Bleck -- 5. Advancing our cell culture platform: incorporating lessons learned and new technologies / Carole Heath -- pt. III. Recovery and purification. 6. Addressing changes associated with technology transfer: a case study / Michele M. Myers ... [et al.] -- 7. Concepts for disposables in biopharmaceutical manufacture / Joachim K. Walter and Uwe Gottschalk -- pt. IV. Formulation and delivery. 8. Formulation and delivery issues for monoclonal antibody therapeutics / Ann L. Daugherty and Randall J. Mrsny -- 9. Challenges in the development of high protein concentration formulations / Steven J. Shire, Zahra Shahrock, and Jun Liu.
10. Protein immobilization by crystallization and precipitation: an alternative to lyophilization / Karoline Bechtold-Peters -- pt. V. Analytics and specification setting for MABS. 11. Characterizing high affinity antigen/antibody complexes by kinetic and equilibrium based methods / Andrew W. Drake, David G. Myszka, and Scott L. Klakamp -- 12. Analytical characterization of monoclonal antibodies: linking structure to function / Reed J. Harris ... [et al.] -- 13. Analysis of irreversible aggregation, reversible self-association and fragmentation of monoclonal antibodies by analytical ultracentrifugation / James D. Andya, Jun Liu, and Steven J. Shires -- 14. Biophysical signatures of monoconal antibodies / N. Harn ... [et al.] -- pt. VI. Pharmacokinetics and immunogenicity. 15. Impact of Fc glycosylation on monoclonal antibody effector functions and degradation by proteases / T. Shantha Raju -- 16. Immunogenicity assessment of antibody therapeutics / P. stas, Y. Gansemans, and I. Lasters -- pt. VII. Armed antibodies and new classes of antibodies. 17. Production of monoclonal antibodies in E. coli / Dorothea E. Reilly and Daniel G. Yansura -- 18. Recent advances in the use of antibody drug conjugates for cancer theapy / Peter D. Senter -- 19. Antibody radiolabeling / Corinne Bensimon and Russell Redshaw.
Electronic reproduction. New York : Springer, 2010. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Aug. 9, 2010). Access may be restricted to users at subscribing institutions.
Includes bibliographical references and index.