http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Organophosphonate caused cardiac toxicity
action potential dynamics in atrial tissue
1 online resource (viii, 15 pages) : illustrations
Highly effective treatments for the effect of organophosphonate and organophosphate (OP) nerve agents have eluded the medical community. It is known that acetylcholine overload is one of the effects of OP toxicity, but the cellular processes leading to cardiac toxicity are still incompletely understood. This study details high performance computer simulations of the electrophysiology in atrial toxicity. It shows that hyperkalemia of the tissue, one of the manifestations of OP intoxication, promotes the processes leading to reentry, a recursor of atrial fibrillation. Then, we demonstrate that changes in two of the potassium membrane currents, i(sub Kr) and i(sub Ks), can modulate the reentry process. This suggests that Class III anti-arrhythmic agents that primarily block these currents in the cardiac cells are important candidates for therapeutics of OP poisoning.
Title from title screen (viewed on Feb. 24, 2011).
Includes bibliographical references (pages 11-12).
Final report; November 2000--August 2001.
U.S. Army Medical Research Institute of Chemical Defense 1U590C 665803.731
Chemical, Biological and Radiological Warfare
ARL-TR (Aberdeen Proving Ground, Md.) ; 2738