rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Organophosphonate caused cardiac toxicity
    sub title: action potential dynamics in atrial tissue
  name:
    name part: Zoltani, Csaba K.
    role:
      role term: creator
  name:
    name part: Baskin, Steven I.
  name:
    name part: U.S. Army Research Laboratory
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: mdu
    date issued: 2002
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (viii, 15 pages) : illustrations
  abstract: Highly effective treatments for the effect of organophosphonate and organophosphate (OP) nerve agents have eluded the medical community. It is known that acetylcholine overload is one of the effects of OP toxicity, but the cellular processes leading to cardiac toxicity are still incompletely understood. This study details high performance computer simulations of the electrophysiology in atrial toxicity. It shows that hyperkalemia of the tissue, one of the manifestations of OP intoxication, promotes the processes leading to reentry, a recursor of atrial fibrillation. Then, we demonstrate that changes in two of the potassium membrane currents, i(sub Kr) and i(sub Ks), can modulate the reentry process. This suggests that Class III anti-arrhythmic agents that primarily block these currents in the cardiac cells are important candidates for therapeutics of OP poisoning.
  note: Title from title screen (viewed on Feb. 24, 2011).
  note: "May 2002."
  note: DTIC reproduction in black and white.
  note: Electronic resource.
  note: Approved for public release.
  note: Includes bibliographical references (pages 11-12).
  note: Final report; November 2000--August 2001.
  note: U.S. Army Medical Research Institute of Chemical Defense 1U590C 665803.731
  subject:
    topic: Cardiovascular toxicology
  subject:
    topic: Phosphates
    topic: Physiological effect
  subject:
    topic: Acetylcholine
    topic: Physiological effect
  subject:
    topic: Medicine and Medical Research
  subject:
    topic: Chemical, Biological and Radiological Warfare
  subject:
    topic: Toxicity
  subject:
    topic: Phosphonates
  subject:
    topic: Cardiovascular system
  subject:
    topic: Organic phosphorus compounds
  subject:
    topic: Computerized simulation
  subject:
    topic: Tissues(biology)
  subject:
    topic: Poisoning
  subject:
    topic: Medical research
  subject:
    topic: Cells(biology)
  subject:
    topic: Nerve agents
  subject:
    topic: Organophosphates
  subject:
    topic: Electrophysiology
  subject:
    topic: Acetylcholine
  subject:
    topic: Intoxication
  subject:
    topic: OP(ORGANOPHOSPHATES)
  subject:
    topic: ATRIAL TISSUE
  classification: D 101.133:2738
  related item:
    title info:
      title: ARL-TR (Aberdeen Proving Ground, Md.) ; 2738
  identifier: https://purl.fdlp.gov/GPO/gpo4329
  access condition: Approved for public release.
  record info:
    record content source: DTICE
    record creation date: 080513
    record change date: 20211120160839.0
    record identifier: in00002639647
    language of cataloging:
      language term: eng