rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Enhancing protein-resistance of PEO-modified biomaterials
  name:
    name part: Murthy, Ranjini.
    role:
      role term: creator
  name:
    name part: Grunlan, Melissa A.
    role:
      role term: thesis advisor.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: txu
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: remote
    extent: 1 online resource.
  abstract: The ultimate goal of this dissertation research is to enhance the protein resistant nature of poly(ethylene oxide) (PEO) or poly(ethylene glycol) by introduction of a siloxane linker and to subsequently prepare coatings which prevent surface-induced thrombosis. The hydrophobicity and flexibility of the siloxane tether should impart both amphiphilicity and conformational mobility to the PEO chain to further decrease protein adhesion. Because adsorption of plasma (blood) proteins initiates the clotting process, coating surfaces based on these new PEO-silanes should prevent or significantly diminish thrombosis. Thus, these coatings would be extremely useful for bloodcontacting medical devices such as stents, grafts, arteriorintravenous shunts, and biosensors. Novel amphiphilic PEO-silanes were prepared with systematic variations to several key structural features, including: siloxane tether length, PEO segment length, and PEO architecture. Thus, PEO-silanes were prepared having the general formulas: [alpha]-(EtO)₃Si(CH₂)₂-oligodimethylsiloxanen-block-[PEO₈-OCH₃] (n = 0, 4, and 13; linear architecture) and [alpha]-(EtO)₃Si(CH₂)₂-oligodimethylsiloxanen-block-[PEOm-OCH₃]₂ (n = 0, 4, and 13; m = 6 and 12 branched architecture). The reactive triethoxysilane [(EtO)₃Si-] group serves as the crosslinking or grafting moiety. The PEO segment is distanced from the (EtO)3Si- group by an oligodimethylsiloxane tether which is both hydrophobic and exhibits a high degree of chain flexibility. Crosslinked silicone coatings and surfacegrafted coatings were prepared with amphiphilic linear PEO-silanes (a-c). Crosslinked silicone coatings were also prepared with branched PEO-silanes (1a-3a and 1b-3b). All coatings showed improved resistance to common plasma proteins compared to silicone coatings. Furthermore, protein adsorption generally decreased with siloxane tether length. For crosslinked PEO-modified silicone coating systems based on linear (a-c) and branched PEO-silanes (1a-3a and 1b…
  note: by Ranjini Murthy.
  note: "Major Subject: Materials Science and Engineering"
  note: Title from author supplied metadata (automated record created 2010-03-12 12:08:51).
  note: Electronic resource.
  note: Doctor of Philosophy Texas A&M University 2009 http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-513
  note: Includes bibliographical references.
  note: Text (Dissertation)
  subject:
    topic: Major Materials Science and Engineering
  subject:
    topic: Thrombosis
  subject:
    topic: Silicones
  subject:
    topic: PEO
  subject:
    topic: Protein resistance
  subject:
    topic: Crosslinked coatings
  subject:
    topic: Surface grafted coatings.
  identifier: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-513
  record info:
    record content source: TXA
    record creation date: 100428
    record change date: 20151201150140.0
    record identifier: in00002595332