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100427s2010 txu sbm 000 0 eng d |
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|a (OCoLC)ocn609713965
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|a (OCoLC)609713965
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|a (TxCM)http://hdl.handle.net/1969.1/ETD-TAMU-3117
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|a TXA
|c TXA
|d UtOrBLW
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|a TXAM
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|a 2008
|a Dissertation
|a 1969.1/ETD-TAMU-3117
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|a Eberth, John Francis.
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|a Arterial biomechanics and the influences of pulsatility on growth and remodeling /
|c by John Francis Eberth.
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|a [College Station, Tex.] :
|b [Texas A&M University],
|c [2010]
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|a 1 online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a "Major Subject: Biomedical Engineering"
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|a Title from author supplied metadata (automated record created 2010-03-12 12:08:51).
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| 502 |
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|b Doctor of Philosophy
|c Texas A&M University
|d 2008
|o http://hdl.handle.net/1969.1/ETD-TAMU-3117
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|a Includes bibliographical references.
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|a Text (Dissertation)
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|a Arterial wall morphology depends strongly on the hemodynamic environment experienced in vivo. The mammalian heart pumps blood through rhythmic contractions forcing blood vessels to undergo cyclic, mechanical stimulation in the form of pulsatile blood pressure and flow. While it has been shown that stepwise, chronic increases in blood pressure and flow modify arterial wall thickness and diameter respectively, few studies on arterial remodeling have examined the influences that pulsatility (i.e., the range of cyclic stimuli) may have on biaxial wall morphology. We experimentally studied the biaxial behavior of carotid arteries from 8 control (CCA), 15 transgenic, and 21 mechanically altered mice using a custom designed mechanical testing device and correlated those results with hemodynamic measurements using pulsed Doppler. In this dissertation, we establish that increased pulsatile stimulation in the right carotid artery after banding (RCCA-B) has a strong affect on wall morphological parameters that peak at 2 weeks and include thickness (CCA=24.8 0.878, RCCA-B=99.0 8.43 m), inner diameter (CCA=530 7.36, RCCA-B=680± 32.0 um), and in vivo axial stretch (CCA=1.7 10.029, RCCAB= 1.19 10.067). These modifications entail stress and the change in stress across the cardiac cycle from an arterial wall macro-structural point of view (i.e., cellular and extracellular matrix) citing increases in collagen mass fraction (CCA=0.223±0.056, RCCA-B=0.314 10.011), collagen to elastin ratio (CCA=0.708±0.152, RCCA-B=1.487±0.26), and cross-sectional cellular nuclei counts (CCA=298±58.9, RCCA-B=578±28.3 cells) at 0, 7, 10, 14, and 42 post-banding surgery. Furthermore, we study the biomechanical properties of carotid arteries from a transgenic mouse of Marfan Syndrome. This arterial disease experiences increased pulse transmission and our findings indicate that alterations occur primarily in the axial direction. The above results are all applied to a predictive biaxial model of Cauchy stress vs. strain.
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|a Electronic resource.
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|a Major biomedical engineering.
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|a pulse pressure
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|a vascular mechanics
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|a arterial growth and remodeling
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|a pulsatile flow
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|a pulsatility
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|a Humphrey, Jay D.,
|e thesis advisor.
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|u http://hdl.handle.net/1969.1/ETD-TAMU-3117
|z Link to OAK Trust copy
|t 0
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| 948 |
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|a cataloged
|b h
|c 2010/4/27
|d c
|e jgreene
|f 5:33:08 pm
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|a C0
|b TXA
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|a MARS
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|i e68787a1-7b63-338a-93e3-471e91637583
|t 0
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| 952 |
f |
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|a Texas A&M University
|b College Station
|c Electronic Resources
|d Available Online
|t 0
|e 2008 Dissertation 1969.1/ETD-TAMU-3117
|h Other scheme
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| 998 |
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|a 2008 Dissertation 1969.1/ETD-TAMU-3117
|t 0
|l Available Online
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