| Tag |
First Indicator |
Second Indicator |
Subfields |
| LEADER |
00000cam a2200000Ka 4500 |
| 001 |
in00002575492 |
| 005 |
20151201150151.0 |
| 006 |
m f d |
| 007 |
cr unu|||||||| |
| 008 |
100428s2010 txu sbm 000 0 eng d |
| 035 |
|
|
|a (OCoLC)ocn609905046
|
| 035 |
|
|
|a (OCoLC)609905046
|
| 035 |
|
|
|a (TxCM)http://hdl.handle.net/1969.1/ETD-TAMU-1277
|
| 040 |
|
|
|a TXA
|c TXA
|d UtOrBLW
|
| 049 |
|
|
|a TXAM
|
| 099 |
|
|
|a 2007
|a Dissertation
|a 1969.1/ETD-TAMU-1277
|
| 100 |
1 |
|
|a Bruce, Erica Dawn.
|
| 245 |
1 |
0 |
|a Modeling toxic endpoints for improving human health risk assessment /
|c by Erica Dawn Bruce.
|
| 264 |
|
1 |
|a [College Station, Tex.] :
|b [Texas A&M University],
|c [2010]
|
| 300 |
|
|
|a 1 online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a "Major Subject: Civil Engineering"
|
| 500 |
|
|
|a Title from author supplied metadata (automated record created 2010-03-12 12:08:51).
|
| 502 |
|
|
|b Doctor of Philosophy
|c Texas A&M University
|d 2007
|o http://hdl.handle.net/1969.1/ETD-TAMU-1277
|
| 504 |
|
|
|a Includes bibliographical references.
|
| 516 |
|
|
|a Text (Dissertation)
|
| 520 |
3 |
|
|a Risk assessment procedures for mixtures of polycyclic aromatic hydrocarbons (PAHs) present a problem due to the lack of available potency and toxicity data on mixtures and individual compounds. This study examines the toxicity of parent compound PAHs and binary mixtures of PAHs in order to bridge the gap between component assessment and mixture assessment. Seven pure parent compound PAHs and four binary mixtures of PAHs were examined in the Salmonella/Microsome Mutagenicity Assay, a Gap Junction Intercellular Communication (GJIC) assay and the 7-ethoxyresorufin-O-deethylase assay (EROD). These assays were chosen for their ability to measure specific toxic endpoints related to the carcinogenic process (i.e. initiation, promotion, progression). Data from these assays was used in further studies to build Quantitative Structure-Activity Relationships (QSARs) to estimate toxic endpoints and to test the additive assumption in PAH mixtures. These QSAR models will allow for the development of bioassay based potential potencies (PPB) or toxic equivalency factors (TEFs) that are derived not only from bioassay data, but also from structure, activity, and physical/chemical properties. These models can be extended to any environmental media to evaluate risk to human health from exposures to PAHs.
|
| 500 |
|
|
|a Electronic resource.
|
| 650 |
|
4 |
|a Major civil engineering.
|
| 653 |
|
|
|a QSARs
|
| 653 |
|
|
|a Risk Assessment
|
| 700 |
1 |
|
|a Autenrieth, Robin L.,
|e thesis advisor.
|
| 856 |
4 |
0 |
|u http://hdl.handle.net/1969.1/ETD-TAMU-1277
|z Link to OAK Trust copy
|t 0
|
| 948 |
|
|
|a cataloged
|b h
|c 2010/4/28
|d c
|e jgreene
|f $:19:36 pm
|
| 994 |
|
|
|a C0
|b TXA
|
| 999 |
|
|
|a MARS
|
| 999 |
f |
f |
|s 06c47e8e-d5e8-3706-9fc3-bcd99d1de2c0
|i 685ad6ac-6eef-3581-b0ca-2b794d82fc17
|t 0
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|d Available Online
|t 0
|e 2007 Dissertation 1969.1/ETD-TAMU-1277
|h Other scheme
|
| 998 |
f |
f |
|a 2007 Dissertation 1969.1/ETD-TAMU-1277
|t 0
|l Available Online
|