rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Parkinson's disease
    sub title: molecular and therapeutic insights from model systems
  name:
    name part: Nass, Richard.
  name:
    name part: Przedborski, Serge.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    date issued: 2008
    edition: 1st ed.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: remote
    extent: xxxiv, 652 pages : illustrations ; 24 cm.
  abstract: Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. * Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson's disease * Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD * Current overviews of current status of PD research and discovery from bench-to-bedside * Provides novel insights and views on where the future of PD research may lead * Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases.
  note: edited by Richard Nass and Serge Przedborski.
  note: Electronic resource.
  note: Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Dec. 9, 2008). Access may be restricted to users at subscribing institutions.
  note: Includes bibliographical references and index.
  subject:
    topic: Parkinson's disease
  subject:
    topic: Biological models
  subject:
    topic: Parkinson Disease
  subject:
    topic: Models, Biological
  subject:
    topic: Parkinson Disease
    topic: genetics
  subject:
    topic: Parkinson Disease
    topic: physiopathology
  classification: RC382 .P37 2008eb
  classification: 616.833
  related item:
    identifier: (OCoLC)166387590
  identifier: 9780123740281
  identifier: 0123740282
  identifier: 139291:139428 Elsevier Science & Technology
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 081212
    record change date: 20260609193353.1
    record identifier: in00002491153
    language of cataloging:
      language term: eng