rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Medicinal chemistry of anticancer drugs
  name:
    name part: Avendaño, Carmen.
    role:
      role term: creator
  name:
    name part: Menéndez, J. Carlos (José Carlos)
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    date issued: 2008
    edition: 1st ed.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: remote
    extent: xv, 442 pages : illustrations ; 25 cm.
  abstract: Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature.
  table of contents: 1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10.Other approaches to targeted therapy -- 11.Drug targeting in anticancer chemotherapy -- 12.Resistance to antitumour agents and drugs that modulate it -- 13.Cancer chemoprevention.
  table of contents: Introduction -- Antimetabolites -- Anticancer drugs that inhibit hormone action -- Anticancer drugs acting via radical species, photosensitizers and photodynamic therapy of cancer -- DNA alkylating agents -- Alkylating and non-alkylating compounds interacting with the DNA minor groove -- DNA intercalators and topoisomerase inhibitors -- Anticancer drugs targeting tubulin and microtubules -- Drugs that inhibit signalling pathways for tumor cell growth and proliferation -- Other approaches to targeted therapy -- Drug targeting in anticancer chemotherapy -- Drugs that modulate resistance to antitumor agents -- Cancer chemoprevention.
  note: Carmen Avendaño and J. Carlos Menéndez.
  note: Electronic resource.
  note: Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Nov. 14, 2008). Access may be restricted to users at subscribing institutions.
  note: Includes bibliographical references and index.
  subject:
    topic: Cancer
    topic: Chemotherapy
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Pharmaceutical chemistry
  classification: RC271.C5 A94 2008eb
  classification: 616.994061
  related item:
    identifier: (OCoLC)227271605
  identifier: 9780444528247
  identifier: 0444528245
  identifier: 114030:114121 Elsevier Science & Technology
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 081117
    record change date: 20260609193702.7
    record identifier: in00002490331
    language of cataloging:
      language term: eng