Target validation in drug discovery /
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug develo...
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
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Amsterdam ; Boston :
Academic Press,
[2007]
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book Publisher description |
MARC
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| 245 | 0 | 0 | |a Target validation in drug discovery / |c editors, Brian W. Metcalf and Susan Dillon. |
| 264 | 1 | |a Amsterdam ; |a Boston : |b Academic Press, |c [2007] | |
| 264 | 4 | |c ©2007 | |
| 300 | |a xii, 279 pages : |b illustrations ; |c 27 cm. | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 533 | |a Electronic reproduction. |b Amsterdam : |c Elsevier Science & Technology, |d 2007. |n Mode of access: World Wide Web. |n System requirements: Web browser. |n Title from title screen (viewed on July 25, 2007). |n Access may be restricted to users at subscribing institutions. | ||
| 520 | |a This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book. | ||
| 505 | 0 | |a Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches. | |
| 504 | |a Includes bibliographical references and index. | ||
| 500 | |a Electronic resource. | ||
| 650 | 0 | |a Drug development. | |
| 650 | 0 | |a Drugs |x Testing. | |
| 650 | 0 | |a High throughput screening (Drug development) | |
| 650 | 1 | 2 | |a Drug Design. |
| 650 | 2 | 2 | |a Drug Delivery Systems. |
| 650 | 2 | 2 | |a Technology, Pharmaceutical. |
| 650 | 6 | |a Médicaments |x Développement. | |
| 650 | 6 | |a Médicaments |x Essais cliniques. | |
| 650 | 6 | |a Criblage à haut débit (Développement des médicaments) | |
| 655 | 7 | |a Electronic books. |2 local | |
| 700 | 1 | |a Metcalf, Brian W. | |
| 700 | 1 | |a Dillon, Susan, |d 1952- | |
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