rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Cancer immunotherapy
    sub title: immune suppression and tumor growth
  name:
    name part: Prendergast, George C.
  name:
    name part: Jaffee, Elizabeth M.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    date issued: 2007
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: remote
    extent: xiii, 409 pages, 4 unnumbered pages of plates : illustrations (some color) ; 27 cm.
  abstract: There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. * Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication * Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research * Summarizes the latest insights into how immune escape defines an essential trait of cancer * Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression.
  table of contents: Part I: Principles of Cancer Immunobiology -- Introduction -- Cancer Immunoediting: From Immune Surveillance to Immune Escape -- Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity -- Cytokine Regulation of Immune Tolerance to Tumors -- Immunological Sculpting: Natural Killer Cell Receptors and Ligands -- Immune Escape: Immunosuppressive Networks -- Part II: Cancer Therapeutics -- Cytotoxic Chemotherapy in Clinical Treatment of Cancer -- Targeted Therapeutics in Cancer Treatment -- Concepts in Pharmacology and Toxicology -- Cancer Immunotherapy: Challenges and Opportunities -- Cancer Vaccines -- Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression -- Immunotherapy and Cancer Therapeutics: Why Partner? -- Immune Stimulatory Features of Classical Chemotherapy -- Dendritic Cells and Co-Inhibitory Molecules -- Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors -- Tumor-associated Macrophages in Cancer Growth and Progression -- Tumor-associated Myeloid-derived Suppressor Cells -- Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune Escape -- IDO in Immune Escape: Regulation and Therapeutic Inhibition -- Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation -- Summary: Future Questions.
  table of contents: Introduction / George C. Prendergast and Elizabeth M. Jaffee -- Cancer immunoediting : from immune surveillance to immune escape / Ryungsa Kim -- Immunosurveillance : innate and adaptive antitumor immunity / Masahisa Jinushi and Glenn Dranoff -- Cytokine regulation of immune tolerance to tumors / Ming O. Li and Richard A. Flavell -- Immunological sculpting : natural killer cell receptors and ligands / David A. Sallman and Julie Y. Djeu -- Immune escape : immunosuppressive networks / Shuang Wei, Alfred Chang, and Weiping Zou -- Cytotoxic chemotherapy in clinical treatment of cancer / Rajesh Thirumaran, George C. Prendergast, and Paul B. Gilman -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Concepts in pharmacology and toxicology / Richard A. Westhouse and Bruce D. Car -- Cancer immunotherapy : challenges and opportunities / Andrew J. Lepisto, John R. McKolanis, and Olivera J. Finn -- Cancer vaccines / Freda K. Stevenson ... [et al.] --
  table of contents: Immunotherapy and cancer therapeutics : why partner? / Leisha A. Emens and Elizabeth M. Jaffee -- Immune stimulatory features of classical chemotherapy / Robbert G. van der Most, Anna K. Nowak, and Richard A. Lake -- Dendritic cells and coregulatory signals : immune checkpoint blockade to stimulate immunotherapy / Drew Pardoll -- Regulatory T cells in tumor immunity : role of toll-like receptors / Rong-Fu Wang -- Tumor-associated macrophages in cancer growth and progression / Alberto Mantovani, Paola Allavena, and Antonio Sica -- Tumor-associated myeloid-derived suppressor cells / Stephanie K. Bunt ... [et al.] -- Programmed death ligand-1 and galectin-1 : pieces in the puzzle of tumor-immune escape / Gabriel A. Rabinovich and Thomas F. Gajewski -- Indoleamine 2,3-dioxygenase in immune escape : regulation and therapeutic inhibition / Alexander J. Muller and George C. Prendergast -- Arginase, nitric oxide synthase, and novel inhibitors of L-arginine metabolism in immune modulation / Susanna Mandruzzato, Simone Mocellin, and Vincenzo Bronte.
  note: edited by George Prendergast, Elizabeth M. Jaffee.
  note: Electronic resource.
  note: Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2007. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Aug. 2, 2007). Access may be restricted to users at subscribing institutions.
  note: Includes bibliographical references and index.
  subject:
    topic: Cancer
    topic: Immunotherapy
  subject:
    topic: Antineoplastic agents
    topic: Therapeutic use
  subject:
    topic: Tumors
    topic: Immunological aspects
  subject:
    topic: Neoplasms
    topic: therapy
  subject:
    topic: Antineoplastic Agents
    topic: therapeutic use
  subject:
    topic: Immunotherapy
    topic: methods
  classification: RC271.I45 C363 2007eb
  classification: 616.99/4061
  classification: 2007 H-238
  classification: QZ 266 C2146 2007
  related item:
    identifier: (DLC) 2007016864
    identifier: (OCoLC)123692348
  identifier: 9780123725516
  identifier: 0123725518
  identifier: 133760:133886 Elsevier Science & Technology
  identifier: http://proxy.library.tamu.edu/login
  identifier: http://www.loc.gov/catdir/toc/ecip0716/2007016864.html
  identifier: http://www.loc.gov/catdir/enhancements/fy0733/2007016864-d.html
  related item:
    location:
      url: http://www.loc.gov/catdir/toc/ecip0716/2007016864.html
  related item:
    location:
      url: http://www.loc.gov/catdir/enhancements/fy0733/2007016864-d.html
  record info:
    record content source: OPELS
    record creation date: 070806
    record change date: 20260609193404.4
    record identifier: in00002425900